Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients: A PET study

Géza Szilágyi, Zoltán Nagy, L. Balkay, István Boros, M. Emri, Szabolcs Lehel, T. Márián, Tamás Molnár, S. Szakáll, L. Trón, D. Bereczki, L. Csiba, I. Fekete, Levente Kerényi, L. Galuska, J. Varga, Péter Bönöczk, Ádám Vas, Balázs Gulyás

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The pharmacological effects of the neuroprotective drug vinpocetine, administered intravenously in a 14-day long treatment regime, on the cerebral blood flow and cerebral glucose metabolism in chronic ischemic stroke patients (n=13) were studied with positron emission tomography in a double-blind design. The regional and global cerebral metabolic rates of glucose (CMRglc) and cerebral blood flow (CBF) as well as vital physiological parameters, clinical performance scales, and transcranial Doppler parameters were measured before and after the treatment period in patient groups treated with daily intravenous infusion with or without vinpocetine. While the global CMR glc values did not change markedly as a result of the infusion treatment with (n=6) or without (n=7) vinpocetine, the global CBF increased and regional CMRglc and CBF values showed marked changes in several brain structures in both cases, with more accentuated changes when the infusion contained vinpocetine. In the latter case the highest rCBF changes were observed in those structures in which the highest regional uptake of labelled vinpocetine was measured in other PET studies (thalamus and caudate nucleus: increases amounting to 36% and 37%, respectively). The findings indicate that a 2-week long intravenous vinpocetine treatment can contribute effectively to the redistribution of rCBF in chronic ischemic stroke patients. The effects are most pronounced in those brain regions with the highest uptake of the drug.

Original languageEnglish
Pages (from-to)275-284
Number of pages10
JournalJournal of the Neurological Sciences
Volume229-230
DOIs
Publication statusPublished - Mar 15 2005

Fingerprint

vinpocetine
Cerebrovascular Circulation
Blood Glucose
Stroke
Glucose
Caudate Nucleus
Brain
Neuroprotective Agents
Therapeutics
Thalamus
Intravenous Infusions
Positron-Emission Tomography
Pharmacology

Keywords

  • Cerebral blood flow
  • Cerebral glucose metabolism
  • Positron emission tomography
  • Stroke
  • Vinpocetine

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Developmental Neuroscience
  • Neurology
  • Neuroscience(all)

Cite this

Effects of vinpocetine on the redistribution of cerebral blood flow and glucose metabolism in chronic ischemic stroke patients : A PET study. / Szilágyi, Géza; Nagy, Zoltán; Balkay, L.; Boros, István; Emri, M.; Lehel, Szabolcs; Márián, T.; Molnár, Tamás; Szakáll, S.; Trón, L.; Bereczki, D.; Csiba, L.; Fekete, I.; Kerényi, Levente; Galuska, L.; Varga, J.; Bönöczk, Péter; Vas, Ádám; Gulyás, Balázs.

In: Journal of the Neurological Sciences, Vol. 229-230, 15.03.2005, p. 275-284.

Research output: Contribution to journalArticle

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AU - Szilágyi, Géza

AU - Nagy, Zoltán

AU - Balkay, L.

AU - Boros, István

AU - Emri, M.

AU - Lehel, Szabolcs

AU - Márián, T.

AU - Molnár, Tamás

AU - Szakáll, S.

AU - Trón, L.

AU - Bereczki, D.

AU - Csiba, L.

AU - Fekete, I.

AU - Kerényi, Levente

AU - Galuska, L.

AU - Varga, J.

AU - Bönöczk, Péter

AU - Vas, Ádám

AU - Gulyás, Balázs

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