Effects of veratridine and its derivatives on the Na-conducting channels in Helix neurons

Tibor Kiss, I. Ujváry

Research output: Contribution to journalArticle

Abstract

Effects of veratrum alkaloids were studied on the Na-channels of the land snail Helix pomatia. It was found that veratridine and its analogues depolarize the membrane due to the increased Na-permeability. The inactivation was shifted right along the voltage axis and the recovery from the inactivation was faster after veratridine treatment. After alkaloid treatment the selectivity of the Na-channel decreased, however, the selectivity sequence was not altered. The activation curve was not shifted. Veratridine derivatives, which appeared to be more effective on insects, had almost no effect on the Na-current.

Original languageEnglish
Pages (from-to)131-143
Number of pages13
JournalActa biologica Hungarica
Volume50
Issue number1-3
Publication statusPublished - Nov 10 1999

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Keywords

  • Channel selectivity
  • Hellix pomatia
  • Molluscan neuron
  • Na-channel
  • Veratridine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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