Effects of ventral pallidal D1 dopamine receptor activation on memory consolidation in morris water maze test

László Péczely, Tamás Ollmann, Kristóf László, Anita Kovács, Rita Gálosi, Ádám Szabó, Zoltán Karádi, L. Lénárd

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In the present experiments, in adult male Wistar rats, the effect of microinjection of the D1 dopamine receptor agonist SKF38393 into the ventral pallidum on memory consolidation, as well as on resistance of the resulting memory trace against extinction were investigated in Morris water maze test. SKF38393 was applied in three doses (0.1, 1.0 or 5.0. μg in 0.4. μl physiological saline, respectively). To clarify whether the effect of the agonist was specific, in a separate group of animals, the D1 dopamine receptor antagonist SCH23390 (5.0. μg in 0.4. μl physiological saline) was administered 15. min prior to 1.0. μg agonist treatment. In another group of animals, the same dose of antagonist was applied by itself.The two lower doses (0.1 and 1.0. μg) of the agonist accelerated memory consolidation relative to controls and increased the stability of the consolidated memory trace against extinction. Antagonist pretreatment eliminated the effects of the agonist, thus confirming that the effect was selectively specific to D1 dopamine receptors. Our findings indicate that the ventral pallidal D1 dopamine receptors are intimately involved in the control of the consolidation processes of spatial memory.

Original languageEnglish
Pages (from-to)211-218
Number of pages8
JournalBehavioural Brain Research
Volume274
DOIs
Publication statusPublished - Nov 1 2014

Fingerprint

2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
Dopamine D1 Receptors
Dopamine Antagonists
Water
Dopamine Agonists
Microinjections
Wistar Rats
Psychological Extinction
Memory Consolidation
Therapeutics
Spatial Memory
SCH 23390
Basal Forebrain

Keywords

  • D1 dopamine receptor
  • Memory consolidation
  • Morris water maze test
  • SCH23390
  • SKF38393
  • Ventral pallidum

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Medicine(all)

Cite this

Effects of ventral pallidal D1 dopamine receptor activation on memory consolidation in morris water maze test. / Péczely, László; Ollmann, Tamás; László, Kristóf; Kovács, Anita; Gálosi, Rita; Szabó, Ádám; Karádi, Zoltán; Lénárd, L.

In: Behavioural Brain Research, Vol. 274, 01.11.2014, p. 211-218.

Research output: Contribution to journalArticle

Péczely, László ; Ollmann, Tamás ; László, Kristóf ; Kovács, Anita ; Gálosi, Rita ; Szabó, Ádám ; Karádi, Zoltán ; Lénárd, L. / Effects of ventral pallidal D1 dopamine receptor activation on memory consolidation in morris water maze test. In: Behavioural Brain Research. 2014 ; Vol. 274. pp. 211-218.
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