Effects of vasopressin analogues (DDAVP, DVDAVP) in the form of sublingual tablets in central diabetes insipidus

F. Laczi, G. Mezei, J. Julesz, F. László

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The effects of 1-deamino-8-D-arginine vasopressin (DDAVP), 1-deamino-4-valin-8-D-arginine vasopressin (DVDAVP) and 8-arginine vasopressin (AVP) on water metabolism have been examined in 18 patients suffering from central diabetes insipidus. The hormone derivatives were sublingually administered. It was established that DDAVP and DVDAVP significantly reduced diuresis and increased urine osmolarity. DVDAVP was found to be more effective than DDAVP. AVP administered in equal doses had no significant effect on water metabolism. The duration of the action of sublingually administered DDAVP was 12 hrs; after dosing DVDAVP the effect lasted even 16 hrs. During one week of DDAVP administration, the accumulation of the drug was indicated by the gradual decrease of diuresis and the increase of the urine osmolarity. The sublingual administration of both DDAVP and DVDAVP tablets (3 x 30 μg/day) has an adequate therapeutic effect.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalInternational Journal of Clinical Pharmacology Therapy and Toxicology
Volume19
Issue number2
Publication statusPublished - 1981

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Neurogenic Diabetes Insipidus
Deamino Arginine Vasopressin
Arginine Vasopressin
Medical problems
Vasopressins
Tablets
Diuresis
Metabolism
Osmolar Concentration
Sublingual Administration
Urine
Water
Therapeutic Uses
Hormones
Derivatives

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Toxicology

Cite this

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abstract = "The effects of 1-deamino-8-D-arginine vasopressin (DDAVP), 1-deamino-4-valin-8-D-arginine vasopressin (DVDAVP) and 8-arginine vasopressin (AVP) on water metabolism have been examined in 18 patients suffering from central diabetes insipidus. The hormone derivatives were sublingually administered. It was established that DDAVP and DVDAVP significantly reduced diuresis and increased urine osmolarity. DVDAVP was found to be more effective than DDAVP. AVP administered in equal doses had no significant effect on water metabolism. The duration of the action of sublingually administered DDAVP was 12 hrs; after dosing DVDAVP the effect lasted even 16 hrs. During one week of DDAVP administration, the accumulation of the drug was indicated by the gradual decrease of diuresis and the increase of the urine osmolarity. The sublingual administration of both DDAVP and DVDAVP tablets (3 x 30 μg/day) has an adequate therapeutic effect.",
author = "F. Laczi and G. Mezei and J. Julesz and F. L{\'a}szl{\'o}",
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AU - Laczi, F.

AU - Mezei, G.

AU - Julesz, J.

AU - László, F.

PY - 1981

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