Effects of two benzo[a]phenothiazines on multi-drug resistance (mdr) and tumor antigen expression

J. Molnár, R. Pusztai, A. Hever, S. Nagy, N. Motohashi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Two benzo[a]phenothiazines 5H-benzo[a]phenothiazin-5-one (1), and its derivative 6-methyl-5H-benzo[a]phenothiazin-5-one (2) inhibited the proliferation of human and mouse tumor cell lines. The multi-drug resistant (mdr) subline was more sensitive than its parent cell line to 5H-benzo[a]phenothiazin-5-one (1). 6-methyl-5H-benzo[a]phenothiazin-5-one (2) was equally antiproliferative against the three cell lines tested. Rhodamine123 efflux of mdr cells was more efficiently inhibited by 5H-benzo[a]phenothiazin-5-one (1) than by 6-methyl-5H-benzo[a]phenothiazin-5-one (2). The exposure of adenovirus infected cells to 5H-benzo[a]phenothiazin-5-one (1) resulted in a reduction of tumour-antigen expression, whereas 6-methyl-5H-benzo[a]phenothiazin-5-one (2) enhanced the T-antigen expression

Original languageEnglish
Pages (from-to)2013-2016
Number of pages4
JournalAnticancer Research
Volume15
Issue number5 B
Publication statusPublished - 1995

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Multiple Drug Resistance
Neoplasm Antigens
Cell Line
Viral Tumor Antigens
Tumor Cell Line
Adenoviridae
Pharmaceutical Preparations
benzophenothiazine

Keywords

  • Adenovirus
  • Benzo[a]phenothiazines
  • Multi-drug resistance
  • Tumor cells

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Effects of two benzo[a]phenothiazines on multi-drug resistance (mdr) and tumor antigen expression. / Molnár, J.; Pusztai, R.; Hever, A.; Nagy, S.; Motohashi, N.

In: Anticancer Research, Vol. 15, No. 5 B, 1995, p. 2013-2016.

Research output: Contribution to journalArticle

Molnár, J, Pusztai, R, Hever, A, Nagy, S & Motohashi, N 1995, 'Effects of two benzo[a]phenothiazines on multi-drug resistance (mdr) and tumor antigen expression', Anticancer Research, vol. 15, no. 5 B, pp. 2013-2016.
Molnár, J. ; Pusztai, R. ; Hever, A. ; Nagy, S. ; Motohashi, N. / Effects of two benzo[a]phenothiazines on multi-drug resistance (mdr) and tumor antigen expression. In: Anticancer Research. 1995 ; Vol. 15, No. 5 B. pp. 2013-2016.
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