Effects of two benzo[a]phenothiazines on multi-drug resistance (mdr) and tumor antigen expression

J. Molnar, R. Pusztai, A. Hever, S. Nagy, N. Motohashi

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Two benzo[a]phenothiazines 5H-benzo[a]phenothiazin-5-one (1), and its derivative 6-methyl-5H-benzo[a]phenothiazin-5-one (2) inhibited the proliferation of human and mouse tumor cell lines. The multi-drug resistant (mdr) subline was more sensitive than its parent cell line to 5H-benzo[a]phenothiazin-5-one (1). 6-methyl-5H-benzo[a]phenothiazin-5-one (2) was equally antiproliferative against the three cell lines tested. Rhodamine123 efflux of mdr cells was more efficiently inhibited by 5H-benzo[a]phenothiazin-5-one (1) than by 6-methyl-5H-benzo[a]phenothiazin-5-one (2). The exposure of adenovirus infected cells to 5H-benzo[a]phenothiazin-5-one (1) resulted in a reduction of tumour-antigen expression, whereas 6-methyl-5H-benzo[a]phenothiazin-5-one (2) enhanced the T-antigen expression

Original languageEnglish
Pages (from-to)2013-2016
Number of pages4
JournalAnticancer research
Volume15
Issue number5 B
Publication statusPublished - Dec 1 1995

    Fingerprint

Keywords

  • Adenovirus
  • Benzo[a]phenothiazines
  • Multi-drug resistance
  • Tumor cells

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Molnar, J., Pusztai, R., Hever, A., Nagy, S., & Motohashi, N. (1995). Effects of two benzo[a]phenothiazines on multi-drug resistance (mdr) and tumor antigen expression. Anticancer research, 15(5 B), 2013-2016.