Effects of two acute stressors on the anxiolytic efficacy of chlordiazepoxide

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Abstract

Rationale: Limited published data show that drug efficacy can be influenced by stressors. Thus, drug testing in stressed animals may unravel important variables determining drug effects. Objectives: The experiments tested the anxiolytic efficacy of the benzodiazepine chlordiazepoxide under conditions of acute stress. Methods: Previously group-housed rats were injected with 0, 3, and 10 mg/kg chlordiazepoxide, thereafter being exposed to two types of stress: novelty (transfer to an individual cage) and social defeat. Controls were group-housed animals. Anxiety was assessed on the plus maze. Results: Speed of locomotion was increased by chlordiazepoxide in both stressed groups but not in controls. Chlordiazepoxide exerted a marked reduction in anxiety in controls and defeated rats but not in novelty exposed animals. The effects of novelty exposure were considerably weaker when drug testing was performed 24 h later. Conclusions: Stress exposure had an impact on the behavioral effects of chlordiazepoxide. Changes in locomotor activity induced by the drug appear to depend on the presence of a stressor, while anxiolytic efficacy appears to depend on the type of the stressor. Since it has been shown that drug efficacy changes in a variety of behavioral situations and drug classes, it is suggested that experimental background is an important variable in determining behavioral effects of drugs.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalPsychopharmacology
Volume151
Issue number1
DOIs
Publication statusPublished - Sep 2 2000

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Keywords

  • Anxiety
  • Anxiolytic
  • Chlordiazepoxide
  • Rat
  • Stress

ASJC Scopus subject areas

  • Pharmacology

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