Effects of trifluoromethyl ketones on the motility of Proteus vulgaris

Krisztina Wolfart, Annamaria Molnar, Masami Kawase, Noboru Motohashi, Joseph Molnar

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6 Citations (Scopus)

Abstract

In the present study, we showed the inhibition of motility by trifluoromethyl ketone (TF) derivatives (1-8) in Proteus vulgaris (P. vulgaris) cultures. Among them, 1-(2-benzoxazoyl)-3,3,3-trifluoro-2-propanone (1) showed a much stronger inhibitory effect on the motility of P. vulgaris than other TF compounds at 10% MIC. Our results suggest the possibility of an inhibitory action of TF compounds on the proton motive forces by affecting the action of biological motor and proton efflux in the membranes, resulting in a reduction of the ratio of running and the increased number of tumbling and non-motile cells.

Original languageEnglish
Pages (from-to)1462-1464
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume27
Issue number9
DOIs
Publication statusPublished - Sep 1 2004

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Keywords

  • Motility
  • Proteus vulgaris
  • Proton pump
  • Trifluoromethyl ketone

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

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