Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells

J. Szebeni, S. S. Patel, K. Hung, L. M. Wahl, J. N. Weinstein

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Abstract

The effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (AZT) were studied in various human mononuclear cell preparations. Thymidine suppressed [3H]AZT phosphorylation in the same concentration range (20 to 100 μM) in which it antagonizes the anti-human immunodeficiency virus activity of AZT. Uridine, in turn, had no influence on AZT phosphorylation, just as it has no effect on the anti-human immunodeficiencyvirus activity of AZT. These findings are consistent with a close relationship between the inhibition of AZT phosphorylation and the influence of physiological nucleosides on the antiviral activity of AZT.

Original languageEnglish
Pages (from-to)198-200
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume35
Issue number1
Publication statusPublished - 1991

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Zidovudine
Uridine
Thymidine
Phosphorylation
Nucleosides
Human Activities
HIV

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Effects of thymidine and uridine on the phosphorylation of 3'-azido-3'-deoxythymidine (zidovudine) in human mononuclear cells. / Szebeni, J.; Patel, S. S.; Hung, K.; Wahl, L. M.; Weinstein, J. N.

In: Antimicrobial Agents and Chemotherapy, Vol. 35, No. 1, 1991, p. 198-200.

Research output: Contribution to journalArticle

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