Effects of therapeutic hypothermia and kinetics of serum protein S100B after cardiopulmonary resuscitation

Ákos Mérei, Bálint János Nagy, Gábor László Woth, Nóra Zsidó, J. Lantos, Diana Mühl

Research output: Contribution to journalArticle

Abstract

Introduction. Post-resuscitation care is regulated by international guidelines. A milestone of these is the application of therapeutic hypothermia (TH). The aims of our study were: to determine the 30-day-mortality for our patients, to monitor the efficacy and effects of TH, and to investigate serum protein S100B – as an early prognostic marker. Materials and Methods. In our study, 57 patients, treated after cardiopulmonary resuscitation (CPR) on a multidisciplinary intensive care unit, were included. Patients were divided into groups who received and who didn’t receive TH. 30-day-mortality was determined as an end-point. Effects of TH were monitored using statistical analysis according to clinical parameters and laboratory tests. Serum protein S100B levels were measured with ELISA technique on 20 randomised patients at admission and the 1st, 3rd and 5th day after CPR. Results. Total 30-day-mortality was 74%. TH did not reduced the 30-day-mortality (73% vs. 74%, p>0.05). We found a significant correlation between TH and serum lactate concentration after admission (0h, p=0.006) and at 12 (p=0.045) and 36 (p=0.049) hours after CPR. On the 3rd (p=0.005) and 4th (p=0.043) day after CPR, as a result of TH, platelet count was significantly higher compared to normothermic samples. There was no significant difference in protein S100B levels between the normothermic and TH group and protein S100B levels did not correlate with 30-day-mortality. Conclusion. Despite recommendations of international guidelines, we cannot prove the beneficial effect of TH, or a correlation of protein S100B levels with a positive outcome.

Original languageEnglish
Pages (from-to)109-130
Number of pages22
JournalSigna Vitae
Volume10
Issue number2
DOIs
Publication statusPublished - Dec 1 2015

Fingerprint

Induced Hypothermia
Cardiopulmonary Resuscitation
Blood Proteins
Mortality
Guidelines
Proteins
Patient Admission
Platelet Count
Resuscitation
Intensive Care Units
Lactic Acid
Enzyme-Linked Immunosorbent Assay

Keywords

  • Cardiac arrest
  • Cardiopulmonary resuscitation
  • Post-resuscitation care
  • Protein S100B
  • Therapeutic hypothermia

ASJC Scopus subject areas

  • Emergency Medicine
  • Critical Care and Intensive Care Medicine

Cite this

Effects of therapeutic hypothermia and kinetics of serum protein S100B after cardiopulmonary resuscitation. / Mérei, Ákos; Nagy, Bálint János; Woth, Gábor László; Zsidó, Nóra; Lantos, J.; Mühl, Diana.

In: Signa Vitae, Vol. 10, No. 2, 01.12.2015, p. 109-130.

Research output: Contribution to journalArticle

Mérei, Ákos ; Nagy, Bálint János ; Woth, Gábor László ; Zsidó, Nóra ; Lantos, J. ; Mühl, Diana. / Effects of therapeutic hypothermia and kinetics of serum protein S100B after cardiopulmonary resuscitation. In: Signa Vitae. 2015 ; Vol. 10, No. 2. pp. 109-130.
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abstract = "Introduction. Post-resuscitation care is regulated by international guidelines. A milestone of these is the application of therapeutic hypothermia (TH). The aims of our study were: to determine the 30-day-mortality for our patients, to monitor the efficacy and effects of TH, and to investigate serum protein S100B – as an early prognostic marker. Materials and Methods. In our study, 57 patients, treated after cardiopulmonary resuscitation (CPR) on a multidisciplinary intensive care unit, were included. Patients were divided into groups who received and who didn’t receive TH. 30-day-mortality was determined as an end-point. Effects of TH were monitored using statistical analysis according to clinical parameters and laboratory tests. Serum protein S100B levels were measured with ELISA technique on 20 randomised patients at admission and the 1st, 3rd and 5th day after CPR. Results. Total 30-day-mortality was 74{\%}. TH did not reduced the 30-day-mortality (73{\%} vs. 74{\%}, p>0.05). We found a significant correlation between TH and serum lactate concentration after admission (0h, p=0.006) and at 12 (p=0.045) and 36 (p=0.049) hours after CPR. On the 3rd (p=0.005) and 4th (p=0.043) day after CPR, as a result of TH, platelet count was significantly higher compared to normothermic samples. There was no significant difference in protein S100B levels between the normothermic and TH group and protein S100B levels did not correlate with 30-day-mortality. Conclusion. Despite recommendations of international guidelines, we cannot prove the beneficial effect of TH, or a correlation of protein S100B levels with a positive outcome.",
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AB - Introduction. Post-resuscitation care is regulated by international guidelines. A milestone of these is the application of therapeutic hypothermia (TH). The aims of our study were: to determine the 30-day-mortality for our patients, to monitor the efficacy and effects of TH, and to investigate serum protein S100B – as an early prognostic marker. Materials and Methods. In our study, 57 patients, treated after cardiopulmonary resuscitation (CPR) on a multidisciplinary intensive care unit, were included. Patients were divided into groups who received and who didn’t receive TH. 30-day-mortality was determined as an end-point. Effects of TH were monitored using statistical analysis according to clinical parameters and laboratory tests. Serum protein S100B levels were measured with ELISA technique on 20 randomised patients at admission and the 1st, 3rd and 5th day after CPR. Results. Total 30-day-mortality was 74%. TH did not reduced the 30-day-mortality (73% vs. 74%, p>0.05). We found a significant correlation between TH and serum lactate concentration after admission (0h, p=0.006) and at 12 (p=0.045) and 36 (p=0.049) hours after CPR. On the 3rd (p=0.005) and 4th (p=0.043) day after CPR, as a result of TH, platelet count was significantly higher compared to normothermic samples. There was no significant difference in protein S100B levels between the normothermic and TH group and protein S100B levels did not correlate with 30-day-mortality. Conclusion. Despite recommendations of international guidelines, we cannot prove the beneficial effect of TH, or a correlation of protein S100B levels with a positive outcome.

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