Effects of the mechanical lesion of the organum vasculosum of the lamina terminalis and of the ovariectomy on the LHRH content of the medio-basal hypothalamus and on the serum LH and FSH levels in adult rats

T. Wenger, B. Kerdelhue

Research output: Contribution to journalArticle

Abstract

The effect of ovariectomy (OVX) and of the lesion of the organum vasculosum of the lamina terminalis (OVLT) on the medio-basal hypothalamic (MBH) LHRH content and on the serum LH and FSH levels was investigated in adult rats. Both the OVX and the OVLT lesion were performed on the same day in cycling animals. The animals were killed 4, 8 and 14 days after the operations. Hypothalamic LHRH content, serum LH and FSH were measured by RIAs. The site of the lesion was checked histologically. The OVX alone resulted in a decrease of LHRH content and in an increase in serum LH and FSH levels. After OVX, combined with OVLT lesion, no decrease in LHRH was observed, while the serum LH and FSH were elevated as in OVX animals alone. The results show that the OVLT plays a definite role in the cyclic but not in the tonic regulation on the secretion of the gonadotropins.

Original languageEnglish
Pages (from-to)85-91
Number of pages7
JournalNeuroendocrinology Letters
Volume2
Issue number2
Publication statusPublished - Jan 1 1980

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ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Clinical Neurology
  • Psychiatry and Mental health

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