A D4 dopamin receptor gén hatása a 6 éves kori viselkedési problémákra.

Translated title of the contribution: Effects of the D4 dopamine receptor gene variation on behavior problems at 6 years of age

Emma Birkás, K. Lakatos, Z. Nemoda, Krisztina Ney, Ildikó Tóth, Alexa Novák, M. Sasvári, J. Gervai

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Association of the 7-repeat allele of the D4 dopamine receptor (DRD4) exon 3 polymorphism with attention deficit/hyperactivity disorder is well-established, and a link with mother-reported aggressiveness was also found in healthy pre-schoolers assessed by the quantitative scale of the Child Behavior Checklist. In the present study, we hypothesized that children carrying the 7-repeat allele would show more attention problems and externalizing (aggressive and delinquent) behavior at 6 years of age. Further, we hypothesized a potential mediating role of early temperament in the relationship of DRD4 gene with behavior problems. Mothers filled in the Achenbach Child Behavior Checklist for 88 six-year-old firstborn children (51 boys, 35 girls) followed from birth. Mother-reported temperament for the same children was assessed by the Rothbart Infant Behavior Questionnaire at 12 months. Genotypes of the DRD4 repeat polymorphism were determined using buccal cells. Significant main effects of gender and DRD4 genotype were observed on 6-year behavioral problems. Boys showed more attention problems and externalizing behavior, and children lacking the 7-repeat variant showed more externalizing and internalizing behavior. These effects remained significant after controlling for 1-year temperament. Our results did not confirm the negative effect of the 7-repeat allele on attention problems and externalizing behavior measured on quantitative scales. On the contrary, we found elevated problem scores in the absence of the 7-repeat allele. Further research including environmental risk factors is needed to clarify the role of the DRD4 gene in the development of externalizing behavior.

Original languageHungarian
Pages (from-to)125-131
Number of pages7
JournalNeuropsychopharmacologia Hungarica
Volume7
Issue number3
Publication statusPublished - 2005

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Dopamine D4 Receptors
Temperament
Child Behavior
Alleles
Mothers
Checklist
Genes
Genotype
Infant Behavior
Cheek
Attention Deficit Disorder with Hyperactivity
Exons
Parturition
Problem Behavior
Research

Cite this

A D4 dopamin receptor gén hatása a 6 éves kori viselkedési problémákra. / Birkás, Emma; Lakatos, K.; Nemoda, Z.; Ney, Krisztina; Tóth, Ildikó; Novák, Alexa; Sasvári, M.; Gervai, J.

In: Neuropsychopharmacologia Hungarica, Vol. 7, No. 3, 2005, p. 125-131.

Research output: Contribution to journalArticle

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