Effects of the amino sugars, glucosamine, mannosamine, or the fluorinated derivative 2-deoxy-fluoroglucose on the phosphatidyl inositol and glycosyl phosphatidyl inositol systems of Tetrahymena

Péter Kovács, György Csaba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Sugar derivatives which have an inhibitory effect on glycosyl phosphatidyl inositol (GPI) synthesis in mammals, primarily prevented 32P incorporation in the unicellular Tetrahymena. Incorporation of 3H-mannose and 3H-inositol was induced by mannosamine. While there was a uniform effect of sugar analogues in mammals, they could not elicit totally similar effects in Tetrahymena. Analogues of sugar also affected synthesis in the phosphatidyl inositol (PI) system. Synthesis of GPI in Tetrahymena was different from that in mammals, but the metabolism of GPI and PI revealed similarities.

Original languageEnglish
Pages (from-to)91-104
Number of pages14
JournalMicrobios
Volume89
Issue number359
Publication statusPublished - Dec 1 1997

Keywords

  • Glycosyl phosphatidyl inositol
  • Phosphatidyl inositol
  • Second messengers
  • Sugar derivatives
  • Tetrahymena

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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