Effects of SZ1677, a new non-depolarizing steroidal neuromuscular blocking drug, and rocuronium on two laryngeal muscles and the anterior tibial muscle in guinea pigs

A. Michalek-Sauberer, E. M. Nicolakis, E. S. Vizi, H. Gilly

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: SZ1677 is a new neuromuscular blocking drug structurally related to rocuronium. We compared the effect of an ED90 of SZ1677 (25 μg/kg) with that of rocuronium (100 μg/kg) in guinea pig laryngeal and peripheral muscles. Methods: Electromyography was used to quantify neuromusc-ular blockade at the posterior cricoarytenoid muscle, the thyroarytenoid muscle and the anterior tibial muscle after SZ1677 (n = 10) and rocuronium (n = 9). Results: Maximum neuromuscular blockade was similar after SZ1677 and rocuronium (83 ± 11% vs. 89 ± 11%; thyroarytenoid muscle: 91 ± 8% vs. 97 ± 3%; anterior tibial muscle: 91 ± 15% vs. 96 ± 3%, respectively). Onset time of neuromuscular blockade at the laryngeal muscles was similar for the two neuromuscular blocking drugs; it was shorter at the thyroarytenoid muscle (67 ± 32 s vs. 42 ± 40 s) than at the posterior cricoarytenoid muscle (101 ± 26 s vs. 102 ± 108 s). Onset time at the anterior tibial muscle was longer after SZ1677 (114 ± 34 s) than after rocuronium (68 ± 46 s); P < 0.05. Neuromuscular recovery was faster after SZ1677 (interval 25%-75%: posterior cricoarytenoid muscle: 222 ± 66 s; thyroarytenoid muscle: 192 ± 92 s; tibial muscle 149 ± 55 s) than after rocuronium (450 ± 148 and 464 ± 183 s, 292 ± 86 s, respectively); P < 0.05. Conclusions: In guinea pigs, SZ1677 offers a rapid onset of neuromuscular blockade at a laryngeal adductor muscle with a shorter duration than rocuronium. Regardless of the drug used, the course of neuromuscular blockade differs not only between peripheral muscles and the larynx but also between antagonistic laryngeal muscles. The differences seem to be species specific.

Original languageEnglish
Pages (from-to)481-487
Number of pages7
JournalActa Anaesthesiologica Scandinavica
Volume50
Issue number4
DOIs
Publication statusPublished - Apr 1 2006

Keywords

  • Anterior tibial muscle
  • Guinea pig
  • Laryngeal muscles
  • Posterior cricoarytenoid muscle
  • Rocuronium
  • SZ1677
  • Thyroarytenoid muscle

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Fingerprint Dive into the research topics of 'Effects of SZ1677, a new non-depolarizing steroidal neuromuscular blocking drug, and rocuronium on two laryngeal muscles and the anterior tibial muscle in guinea pigs'. Together they form a unique fingerprint.

  • Cite this