Effects of systemic PACAP treatment in monosodium glutamate-induced behavioral changes and retinal degeneration

P. Kiss, A. Tamás, A. Lubics, I. Lengvári, M. Szalai, D. Hauser, Z. S. Horvath, B. Rácz, R. Gábriel, N. Babai, G. Tóth, D. Reglodi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The present article investigated effects of systemic pituitary adenylate cyclase-activating polypeptide (PACAP) treatment in monosodium glutamate (MSG)-induced retinal degeneration and neurobehavioral alterations in neonatal rats. It was found that the dose of PACAP that effectively enhances neurobehavioral development in normal rats was able to counteract the retarding effect of MSG on righting, forelimb placing, and grasp reflexes and caused a significant amelioration of the righting and gait reflex performance and motor coordination at 2 weeks of age. In the retina, significant amelioration of neuronal loss in the inner retinal layers was achieved, but it was much less than that observed by local administration.

Original languageEnglish
Pages (from-to)365-370
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1070
DOIs
Publication statusPublished - Jul 2006

Fingerprint

Pituitary Adenylate Cyclase-Activating Polypeptide
Sodium Glutamate
Retinal Degeneration
Rats
Righting Reflex
Forelimb
Hand Strength
Gait
Reflex
Retina
Therapeutics
Degeneration
Rat
Local Administration
Alteration
Layer
Dose

Keywords

  • Neonatal rat
  • Neurobehavioral development
  • Retinotoxicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

@article{c1de605c32f14682af8ab177d9693ca2,
title = "Effects of systemic PACAP treatment in monosodium glutamate-induced behavioral changes and retinal degeneration",
abstract = "The present article investigated effects of systemic pituitary adenylate cyclase-activating polypeptide (PACAP) treatment in monosodium glutamate (MSG)-induced retinal degeneration and neurobehavioral alterations in neonatal rats. It was found that the dose of PACAP that effectively enhances neurobehavioral development in normal rats was able to counteract the retarding effect of MSG on righting, forelimb placing, and grasp reflexes and caused a significant amelioration of the righting and gait reflex performance and motor coordination at 2 weeks of age. In the retina, significant amelioration of neuronal loss in the inner retinal layers was achieved, but it was much less than that observed by local administration.",
keywords = "Neonatal rat, Neurobehavioral development, Retinotoxicity",
author = "P. Kiss and A. Tam{\'a}s and A. Lubics and I. Lengv{\'a}ri and M. Szalai and D. Hauser and Horvath, {Z. S.} and B. R{\'a}cz and R. G{\'a}briel and N. Babai and G. T{\'o}th and D. Reglodi",
year = "2006",
month = "7",
doi = "10.1196/annals.1317.046",
language = "English",
volume = "1070",
pages = "365--370",
journal = "Annals of the New York Academy of Sciences",
issn = "0077-8923",
publisher = "Wiley-Blackwell",

}

TY - JOUR

T1 - Effects of systemic PACAP treatment in monosodium glutamate-induced behavioral changes and retinal degeneration

AU - Kiss, P.

AU - Tamás, A.

AU - Lubics, A.

AU - Lengvári, I.

AU - Szalai, M.

AU - Hauser, D.

AU - Horvath, Z. S.

AU - Rácz, B.

AU - Gábriel, R.

AU - Babai, N.

AU - Tóth, G.

AU - Reglodi, D.

PY - 2006/7

Y1 - 2006/7

N2 - The present article investigated effects of systemic pituitary adenylate cyclase-activating polypeptide (PACAP) treatment in monosodium glutamate (MSG)-induced retinal degeneration and neurobehavioral alterations in neonatal rats. It was found that the dose of PACAP that effectively enhances neurobehavioral development in normal rats was able to counteract the retarding effect of MSG on righting, forelimb placing, and grasp reflexes and caused a significant amelioration of the righting and gait reflex performance and motor coordination at 2 weeks of age. In the retina, significant amelioration of neuronal loss in the inner retinal layers was achieved, but it was much less than that observed by local administration.

AB - The present article investigated effects of systemic pituitary adenylate cyclase-activating polypeptide (PACAP) treatment in monosodium glutamate (MSG)-induced retinal degeneration and neurobehavioral alterations in neonatal rats. It was found that the dose of PACAP that effectively enhances neurobehavioral development in normal rats was able to counteract the retarding effect of MSG on righting, forelimb placing, and grasp reflexes and caused a significant amelioration of the righting and gait reflex performance and motor coordination at 2 weeks of age. In the retina, significant amelioration of neuronal loss in the inner retinal layers was achieved, but it was much less than that observed by local administration.

KW - Neonatal rat

KW - Neurobehavioral development

KW - Retinotoxicity

UR - http://www.scopus.com/inward/record.url?scp=33746417939&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33746417939&partnerID=8YFLogxK

U2 - 10.1196/annals.1317.046

DO - 10.1196/annals.1317.046

M3 - Article

C2 - 16888193

AN - SCOPUS:33746417939

VL - 1070

SP - 365

EP - 370

JO - Annals of the New York Academy of Sciences

JF - Annals of the New York Academy of Sciences

SN - 0077-8923

ER -