Effects of systemic kainic acid administration on regional Na+,K+-ATPase activity in rat brain

L. Sztriha, F. Joo, L. Dux, Z. Boti

Research output: Contribution to journalArticle

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Abstract

Changes in the activity of Na+,K+-ATPase and in the water, Na+, and K+ levels in the parietal cortex, hippocampus, and thalamus were investigated in rats 1, 3, 6, and 24 h following systemic kainic acid injection. An increase in Na+,K+-ATPase activity was observed in all three regions 3 h after the treatment, with a subsequent decrease in enzyme activity. The elevation in Na+,K+-ATPase activity was accompanied by an increase in the Na+ content and a decrease in the K+ content. These changes are presumed to occur because of repeated discharges and excessive prolonged depolarization in response to kainic acid. The decreases in Na+,K+-ATPase activity 6 and 24 h following kainic acid treatment coincide with neuropathological damage and edema formation, mainly in the hippocampus and thalamus.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalJournal of Neurochemistry
Volume49
Issue number1
Publication statusPublished - 1987

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Kainic Acid
Adenosine Triphosphatases
Rats
Brain
Thalamus
Hippocampus
Parietal Lobe
Depolarization
Enzyme activity
Edema
Injections
sodium-translocating ATPase
Water
Enzymes
Therapeutics

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

Cite this

Effects of systemic kainic acid administration on regional Na+,K+-ATPase activity in rat brain. / Sztriha, L.; Joo, F.; Dux, L.; Boti, Z.

In: Journal of Neurochemistry, Vol. 49, No. 1, 1987, p. 83-87.

Research output: Contribution to journalArticle

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