Effects of Systemic Kainic Acid Administration on Regional Na+, K+‐ATPase Activity in Rat Brain

L. Sztriha, F. Joó, L. Dux, Zsuzsanna Böti

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Abstract: Changes in the activity of Na+, K+‐ATPase and in the water, Na+, and K+ levels in the parietal cortex, hippocampus, and thalamus were investigated in rats 1, 3, 6, and 24 h following systemic kainic acid injection. An increase in Na+, K+‐ATPase activity was observed in all three regions 3 h after the treatment, with a subsequent decrease in enzyme activity. The elevation in Na+,K+‐ATPase activity was accompanied by an increase in the Na+ content and a decrease in the K+ content. These changes are presumed to occur because of repeated discharges and excessive prolonged depolarization in response to kainic acid. The decreases in Na+,K+‐ATPase activity 6 and 24 h following kainic acid treatment coincide with neuropathological damage and edema formation, mainly in the hippocampus and thalamus.

Original languageEnglish
Pages (from-to)83-87
Number of pages5
JournalJournal of neurochemistry
Issue number1
Publication statusPublished - Jul 1987



  • Kainic acid
  • Na,K‐ATPase
  • Potassium content
  • Rats
  • Sodium content
  • Water content

ASJC Scopus subject areas

  • Biochemistry
  • Cellular and Molecular Neuroscience

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