Effects of stress on the metabolism of noradrenaline, dopamine and serotonin (5HT) in the central nervous system of the rat (II) modifications of serotonin metabolism

Anne Marie Thierry, Márton Fekete, Jacques Glowinski

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

The formation of 3H-serotonin (5HT) from 3H-tryptophan (TRY) in vivo and its utilization have been studied in the rat brain. The effect of stress induced by mild electric shocks applied to the feet on 5HT synthesis and utilization was examined. This stress led to a slight increase in the 5HT level in the brain stem-mesencephalon; this effect was enhanced in animals pretreated 42 hr earlier with a tryptophan hydroxylase inhibitor (p-chlorophenylalamine). The formation of 3H-5HT from 3H-TRY was significantly increased in the brain of stressed animals and the utilization of this labelled amine synthesized endogenously was markedly accelerated during the stress situation.

Original languageEnglish
Pages (from-to)384-389
Number of pages6
JournalEuropean Journal of Pharmacology
Volume4
Issue number4
DOIs
Publication statusPublished - Nov 1968

Keywords

  • metabolism
  • serotonin
  • stress

ASJC Scopus subject areas

  • Pharmacology

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