Effects of stress on catecholamines and tyrosine hydroxylase activity of individual hypothalamic nuclei

M. Palkovits, R. M. Kobayashi, J. S. Kizer, D. M. Jacobowitz, I. J. Kopin

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The effects of acute stress on norepinephrine (NE) and dopamine (DA) concentrations and of repeated stress on tyrosine hydroxylase (TH) activity were measured in individual hypothalamic nuclei and other rat brain regions. A microdissection technique and radioisotopic enzymatic assays enabled these studies to be performed. NE and DA concentrations were reduced and TH activity increased selectively in the arcuate nucleus. These results suggest that the arcuate nucleus may be selectively involved in the stress response and support the hypothesis that catecholamines in the medial basal hypothalamus mediate certain of the neuroendocrine changes observed in stress.

Original languageEnglish
Pages (from-to)144-153
Number of pages10
JournalUnknown Journal
Issue number2
Publication statusPublished - Jan 1 1975


ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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