Effects of somatostatin on self-stimulation behaviour in rats pretreated with a receptor blocker

Mária Balázs, Helmut Schwarzberg, Gyula Telegdy

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effects of somatostatin on lateral hypothalamic self-stimulation were investigated in rats pretreated with haloperidol, bicuculline, phenoxybenzamine or propranolol. Somatostatin decreased the rate of self-stimulation. Halperidol, bicuculline and phenoxybenzamine potentiated the somatostatin-induced depression of self-stimulation behaviour. Propranolol had no effect. It is suggested that dopaminergic, GABAergic and noradrenergic systems are involved in the somatostatin-induced depression of self-stimulation.

Original languageEnglish
Pages (from-to)141-144
Number of pages4
JournalEuropean Journal of Pharmacology
Volume149
Issue number1-2
DOIs
Publication statusPublished - Apr 27 1988

Keywords

  • Bicuculline
  • Haloperidol
  • Phenoxybenzamine
  • Propranolol
  • Self-stimulation
  • Somatostatin

ASJC Scopus subject areas

  • Pharmacology

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