Effects of somatostatin and anti-somatostatin serum on picrotoxin-kindled seizures

A. M. Mazarati, G. Telegdy

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

The effects of somatostatin, administered into different areas of the brain were studied in preliminary picrotoxin-kindled rats. The injection of somatostatin into the lateral ventrical of the brain (i.c.v.) (1.8 nmol), the hippocampus (0.6 nmol) or the amygdala (0.6 nmol), resulted in a decrease in the severity of the picrotoxin-induced convulsions. Application of the peptide into the caudate-putamen or the substantia nigra reticulata did not alter the behavioural manifestations of the kindled Seizures. The local injection of anti-somatostatin serum (1:5) into the hippocampus increased the severity of the kindled convulsions and blocked the anticonvulsive effect of somatostatin, given intraventricularly. Local administration of anti-somatostatin serum into the amygdala did not alter the kindled Scizures and did not abolish the anticonvulsive action of somatostatin given intraventricularly. It is concluded that somatostatin could take part in endogenous control of Scizures through a suppressant influence on limbic structures; the hippocampus could be a specific site for the antiepileptic action of somatostatin.

Original languageEnglish
Pages (from-to)793-797
Number of pages5
JournalNeuropharmacology
Volume31
Issue number8
DOIs
Publication statusPublished - Aug 1992

Keywords

  • brain structures
  • kindling
  • somatostatin

ASJC Scopus subject areas

  • Pharmacology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Effects of somatostatin and anti-somatostatin serum on picrotoxin-kindled seizures'. Together they form a unique fingerprint.

  • Cite this