Effects of sodium diethyldithiocarbamate on type II pulmonary epithelial cells in vitro

E. Tátrai, Zuzana Kováciková, Géza Karácsony, Aranka Hudák, Zoltán Adamis, György Ungváry

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Dithiocarbamates (DDTC) are chemicals widely used in the form of pesticides, therapeutic and chelating agents, and scavengers. Since DDTC interfere with SH, Cu, and Zn enzymes due to chelating properties, it was of interest to clarify, in primary culture of type II alveolar pneumocytes, the effect of this compound upon enzymes of glutathione cycle, Cu, Zn-superoxide dismutase, and the membrane structure of cells. DDTC significantly inhibited the activity of superoxide dismutase and the activity of gamma-glutamyl transpeptidase, glutathione reductase, and alkaline phosphatase, whereas an increase in the activity of glutathione peroxidase was found. The membranes of pneumocytes type II were injured. Data show that DDTC adversely affected type II pneumocyte function and structure.

Original languageEnglish
Pages (from-to)207-216
Number of pages10
JournalJournal of Toxicology and Environmental Health - Part A
Volume62
Issue number3
DOIs
Publication statusPublished - Feb 9 2001

Fingerprint

Alveolar Epithelial Cells
Ditiocarb
Epithelial Cells
Sodium
sodium
enzyme
Chelation
membrane
Lung
Membrane structures
chelating agent
gamma-Glutamyltransferase
Glutathione Reductase
scavenger
Enzymes
Chelating Agents
Glutathione Peroxidase
Cell Membrane Structures
Pesticides
phosphatase

ASJC Scopus subject areas

  • Environmental Science(all)
  • Environmental Chemistry
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Effects of sodium diethyldithiocarbamate on type II pulmonary epithelial cells in vitro. / Tátrai, E.; Kováciková, Zuzana; Karácsony, Géza; Hudák, Aranka; Adamis, Zoltán; Ungváry, György.

In: Journal of Toxicology and Environmental Health - Part A, Vol. 62, No. 3, 09.02.2001, p. 207-216.

Research output: Contribution to journalArticle

Tátrai, E. ; Kováciková, Zuzana ; Karácsony, Géza ; Hudák, Aranka ; Adamis, Zoltán ; Ungváry, György. / Effects of sodium diethyldithiocarbamate on type II pulmonary epithelial cells in vitro. In: Journal of Toxicology and Environmental Health - Part A. 2001 ; Vol. 62, No. 3. pp. 207-216.
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