Effects of smoking cessation and nicotine substitution on systemic eicosanoid production in man

V. Saareks, P. Ylitalo, J. Alanko, I. Muchá, A. Riutta

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

This study investigated the effects of smoking cessation with and without nicotine substitution on the excretion of major urinary metabolites of thromboxane A2 and prostacyclin, 11-dehydrothromboxane B2 and 2,3-dinor-6-ketoprostaglandin F, respectively, as well as on the excretion of leukotriene E4 in man. Urine samples were obtained from 20 healthy non-smoking controls and from 60 healthy smoking volunteers before, and 3, 7 and 14 days after smoking cessation. Fifteen smokers quit smoking without nicotine substitution, 15 used nicotine chewing gum and 30 used nicotine patches as a substitution therapy. Urinary thiocyanate as well as cotinine and trans-3′-hydroxycotinine excretions were used as compliance and nicotine substitution indicators. 11-Dehydrothromboxane B2, 2,3-dinor-6-ketoprostaglandin F and leukotriene E4 excretion was about two, three and five times higher in smokers than in controls, respectively. Three days after smoking cessation without nicotine substitution, 11-dehydrothromboxane B2 and 2,3-dinor-6-ketoprostaglandin F levels were lowered to 75% (P4 excretion was dropped to 70% of the initial value (P

Original languageEnglish
Pages (from-to)556-561
Number of pages6
JournalNaunyn-Schmiedeberg's Archives of Pharmacology
Volume363
Issue number5
DOIs
Publication statusPublished - 2001

Fingerprint

Eicosanoids
Smoking Cessation
Nicotine
Leukotriene E4
Tobacco Use Cessation Products
Smoking
Cotinine
Thromboxane A2
Epoprostenol
Compliance
Healthy Volunteers
Urine
11-dehydro-thromboxane B2
Therapeutics

Keywords

  • Leukotrienes
  • Nicotine
  • Prostacyclin
  • Smoking
  • Thromboxanes

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of smoking cessation and nicotine substitution on systemic eicosanoid production in man. / Saareks, V.; Ylitalo, P.; Alanko, J.; Muchá, I.; Riutta, A.

In: Naunyn-Schmiedeberg's Archives of Pharmacology, Vol. 363, No. 5, 2001, p. 556-561.

Research output: Contribution to journalArticle

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