Effects of septic shock plasma on adrenocortical cell function

G. Kéri, V. Parameswaran, Donald D. Trunkey, J. Ramachandran

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

The effects of septic shock plasma on adrenocortical cell function have been studied using primary cultures of rat adrenocortical cells. Whereas control plasma had no adverse effect on the stimulation of corticosterone production by corticotropin (ACTH), shock plasma caused a 40%, noncompetitive inhibition of ACTH-induced steroidogenesis. The inhibitory effect was maximal at 24 h and appeared to be due to the action of shock plasma on the cells rather than the hormone. E. coli endotoxins did not have any effect on the responsiveness of the cells. These results suggest that septic shock plasma contains factor(s) which attenuate the responsiveness of adrenocortical cells to ACTH, thereby affecting the ability of the shocked animal to cope with sepsis.

Original languageEnglish
Pages (from-to)1917-1923
Number of pages7
JournalLife Sciences
Volume28
Issue number17
DOIs
Publication statusPublished - Apr 27 1981

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Septic Shock
Adrenocorticotropic Hormone
Plasmas
Shock
Corticosterone
Plasma Cells
Endotoxins
Sepsis
Escherichia coli
Hormones
Rats
Animals

ASJC Scopus subject areas

  • Pharmacology

Cite this

Kéri, G., Parameswaran, V., Trunkey, D. D., & Ramachandran, J. (1981). Effects of septic shock plasma on adrenocortical cell function. Life Sciences, 28(17), 1917-1923. https://doi.org/10.1016/0024-3205(81)90299-X

Effects of septic shock plasma on adrenocortical cell function. / Kéri, G.; Parameswaran, V.; Trunkey, Donald D.; Ramachandran, J.

In: Life Sciences, Vol. 28, No. 17, 27.04.1981, p. 1917-1923.

Research output: Contribution to journalArticle

Kéri, G, Parameswaran, V, Trunkey, DD & Ramachandran, J 1981, 'Effects of septic shock plasma on adrenocortical cell function', Life Sciences, vol. 28, no. 17, pp. 1917-1923. https://doi.org/10.1016/0024-3205(81)90299-X
Kéri, G. ; Parameswaran, V. ; Trunkey, Donald D. ; Ramachandran, J. / Effects of septic shock plasma on adrenocortical cell function. In: Life Sciences. 1981 ; Vol. 28, No. 17. pp. 1917-1923.
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