Effects of selective phosphodiesterase-5-inhibition on myocardial contractility and reperfusion injury after heart transplantation

Sivakkanan Loganathan, T. Radovits, Kristóf Hirschberg, Sevil Korkmaz, Eniko Barnucz, Matthias Karck, G. Szabó

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Recently, the infarct reducing and cardioprotective effects of phosphodiesterase-5-inhibitors were described. In this study, we investigated these effects on ischemia/reperfusion injury in a rat model of heart transplantation. Three groups were assigned for our study: a vardenafil preconditioning group, an ischemic control, and a nonischemic control. Hemodynamic parameters were significantly increased in the vardenafil group (Pmax: 82±4 vs. 110±12 vs. 127±13 mm Hg; dP/dtmax: 1740±116 vs. 3197±599 vs. 4397±602 mm Hg/sec; ischemic control vs. vardenafil vs. nonischemic control; P

Original languageEnglish
Pages (from-to)1414-1418
Number of pages5
JournalTransplantation
Volume86
Issue number10
DOIs
Publication statusPublished - Nov 27 2008

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Type 5 Cyclic Nucleotide Phosphodiesterases
Myocardial Reperfusion Injury
Heart Transplantation
Phosphodiesterase 5 Inhibitors
Ischemic Preconditioning
Reperfusion Injury
Hemodynamics
Control Groups
Vardenafil Dihydrochloride

Keywords

  • Vardenafil, Phosphodiesterase-5, Transplantation, Ischemia/reperfusion, cGMP.

ASJC Scopus subject areas

  • Transplantation

Cite this

Effects of selective phosphodiesterase-5-inhibition on myocardial contractility and reperfusion injury after heart transplantation. / Loganathan, Sivakkanan; Radovits, T.; Hirschberg, Kristóf; Korkmaz, Sevil; Barnucz, Eniko; Karck, Matthias; Szabó, G.

In: Transplantation, Vol. 86, No. 10, 27.11.2008, p. 1414-1418.

Research output: Contribution to journalArticle

Loganathan, Sivakkanan ; Radovits, T. ; Hirschberg, Kristóf ; Korkmaz, Sevil ; Barnucz, Eniko ; Karck, Matthias ; Szabó, G. / Effects of selective phosphodiesterase-5-inhibition on myocardial contractility and reperfusion injury after heart transplantation. In: Transplantation. 2008 ; Vol. 86, No. 10. pp. 1414-1418.
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