Effects of selective breeding for increased wheel-running behavior on circadian timing of substrate oxidation and ingestive behavior

I. Jónás, L. M. Vaanholt, M. Doornbos, Jr Garland, A. J W Scheurink, C. Nyakas, G. van Dijk

Research output: Contribution to journalArticle

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Abstract

Fluctuations in substrate preference and utilization across the circadian cycle may be influenced by the degree of physical activity and nutritional status. In the present study, we assessed these relationships in control mice and in mice from a line selectively bred for high voluntary wheel-running behavior, either when feeding a carbohydrate-rich/low-fat (LF) or a high-fat (HF) diet. Housed without wheels, selected mice, and in particular the females, exhibited higher cage activity than their non-selected controls during the dark phase and at the onset of the light phase, irrespective of diet. This was associated with increases in energy expenditure in both sexes of the selection line. In selected males, carbohydrate oxidation appeared to be increased compared to controls. In contrast, selected females had profound increases in fat oxidation above the levels in control females to cover the increased energy expenditure during the dark phase. This is remarkable in light of the finding that the selected mice, and in particular the females showed higher preference for the LF diet relative to controls. It is likely that hormonal and/or metabolic signals increase carbohydrate preference in the selected females, which may serve optimal maintenance of cellular metabolism in the presence of augmented fat oxidation.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalPhysiology and Behavior
Volume99
Issue number5
DOIs
Publication statusPublished - Apr 2010

Fingerprint

Running
Fats
Carbohydrates
Energy Metabolism
Sex Preselection
Fat-Restricted Diet
High Fat Diet
Nutritional Status
Maintenance
Selective Breeding
Diet
Light

Keywords

  • Macronutrient selection
  • Respiratory quotient
  • Substrate oxidation
  • Voluntary activity

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology

Cite this

Effects of selective breeding for increased wheel-running behavior on circadian timing of substrate oxidation and ingestive behavior. / Jónás, I.; Vaanholt, L. M.; Doornbos, M.; Garland, Jr; Scheurink, A. J W; Nyakas, C.; van Dijk, G.

In: Physiology and Behavior, Vol. 99, No. 5, 04.2010, p. 549-554.

Research output: Contribution to journalArticle

Jónás, I. ; Vaanholt, L. M. ; Doornbos, M. ; Garland, Jr ; Scheurink, A. J W ; Nyakas, C. ; van Dijk, G. / Effects of selective breeding for increased wheel-running behavior on circadian timing of substrate oxidation and ingestive behavior. In: Physiology and Behavior. 2010 ; Vol. 99, No. 5. pp. 549-554.
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