Effects of secretin on acute and chronic effects of morphine

Emese Babarczy, Gyula Szabó, Gyula Telegdy

Research output: Contribution to journalArticle

15 Citations (Scopus)


The effects of intracerebroventricularly (ICV) administered secretin on the analgesic, tolerance-inducing, and dependence-inducing actions of morphine were investigated, in adult, male CFLP mice. Secretin administered doses ICV did not itself affect pain sensitivity in a heat-radiant tail flick test. However, it depressed the acute nociceptive effect of a single subcutaneous (SC) dose of morphine (4 mg/kg) after ICV (1 or 10 ng/ animal) secretin administration. A dose of 10 ng secretin facilitated the development of acute morphine tolerance. On the other hand, none of the doses applied had any influence on chronic morphine tolerance, where animals were implanted SC with a morphine- containing pellet and the pain sensitivity was measured 3 days later. Morphine withdrawal signs were also evaluated by injecting naloxone. In a 100-ng dose, secretin increased the latency of the withdrawal jumping response; the peptide did not modify the other abstinence signs. These data suggest that central secretin administration can modify the analgesic effect of morphine.

Original languageEnglish
Pages (from-to)469-472
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Issue number2-3
Publication statusPublished - Jan 1 1995


  • Dependence
  • Morphine
  • Pain
  • Secretin
  • Tail flick
  • Tolerance

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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