Effects of salsolinol and its antagonistic analogue, 1-MeDIQ, on growth hormone release in nursing sheep

Konrad Górski, Katarzyna Romanowicz, Edyta Molik, Ferenc Fülöp, Tomasz Misztal

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Suckling induces a GH surge simultaneously to that of prolactin, so we tested whether salsolinol, a dopamine derivative (1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline), participates in the regulatory process of GH secretion in lactating sheep. A series of intracerebroventricular (i.c.v.) infusions of salsolinol, in two doses, was performed in nursing sheep, without suckling, during the fifth week of lactation. In other suckling sheep, we infused i.c.v. a structural analogue of salsolinol-1-methyl-3,4-dihydroisoqinoline (1-MeDIQ), which is able to antagonize salsolinol's action. Intracerebroventricular treatment of nursing sheep with a lower dose of salsolinol (total 50 ng) significantly increased plasma GH concentration, as compared with the concentrations noted before the infusion and in nursing controls. A higher dose of salsolinol (total 5 μg) did not affect GH release significantly. Intracerebroventricular treatment with 1-MeDIQ (total 300 μg) significantly reduced basal GH release, not affecting a pattern of GH surge in response to suckling. In conclusion, salsolinol may affect the regulatory process of GH secretion in lactating sheep, but its role seems not to be major.

Original languageEnglish
Pages (from-to)20-27
Number of pages8
JournalActa neurobiologiae experimentalis
Volume70
Issue number1
Publication statusPublished - May 18 2010

Keywords

  • 1-MeDIQ
  • Growth hormone
  • Lactation
  • Nursing sheep
  • Salsolinol

ASJC Scopus subject areas

  • Neuroscience(all)

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