Effects of salbutamol and Ro-20-1724 on airway and parenchymal mechanics in rats

Ferenc Peták, Janet L. Wale, Peter D. Sly

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Abstract

We investigated the effects of a selective β2-agonist, salbutamol, and of phosphodiesterase type 4 inhibition with 4-(3-butoxy-4-methoxy benzyl)-2- imidazolidinone (Ro-201724) on the airway and parenchymal mechanics during steady-state constriction induced by MCh administered as an aerosol or intravenously (iv). The wave-tube technique was used to measure the lung input impedance (ZL) between 0.5 and 20 Hz in 31 anesthetized, paralyzed, open-chest adult Brown Norway rats. To separate the airway and parenchymal responses, a model containing an airway resistance (Raw) and inertance (Iaw), and a parenchymal damping (G) and elastance (H), was fitted to ZL spectra under control conditions, during steady-state constriction, and after either salbutamol or Ro-20-1724 delivery. In the Brown Norway rat, the response to iv MCh infusion was seen in Raw and G, whereas continuous aerosolized MCh challenge produced increases in G and H only. Both salbutamol, administered either as an aerosol or iv, and Ro-20-1724 significantly reversed the increases in Raw and G when MCh was administered iv. During the MCh aerosol challenge, Ro-20-1724 significantly reversed the increases in G and H, whereas salbutamol had no effect. These results suggest that, after MCh- induced changes in lung function, salbutamol increases the airway caliber. Ro-20-1724 is effective in reversing the airway narrowings, and it may also decrease the parenchymal constriction.

Original languageEnglish
Pages (from-to)1373-1380
Number of pages8
JournalJournal of Applied Physiology
Volume87
Issue number4
DOIs
Publication statusPublished - Oct 1999

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Keywords

  • Airway resistance
  • Bronchodilators
  • Forced oscillation
  • Tissue resistance

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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