Effects of rs769217 and rs1001179 polymorphisms of catalase gene on blood catalase, carbohydrate and lipid biomarkers in diabetes mellitus

László Góth, Teréz Nagy, Zsuzsanna Kósa, Zsolt Fejes, Harjit Pal Bhattoa, György Paragh, Miklós Káplár

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Oxidative stress and deficiency of the enzyme catalase, which is the primary scavenger of the oxidant H2O2, may contribute to diabetes. The current study examined two polymorphisms in the catalase gene,-262C>nT in the promoter and 111C>T in exon 9, and their effects on blood catalase activity as well as on concentrations of blood glucose, haemoglobin A1c, triglyceride, cholesterol, HDL, LDL, ApoA-I and ApoB. Subjects were type-1 and type-2 diabetics. We evaluated PCR-single strand conformational polymorphism for 111C>T and PCR-restriction fragment length polymorphism for-262C>T. TT genotype frequency of 111C>T polymorphism was increased in type-1 diabetes. Type-2 diabetics with the CC or CT genotypes had decreased catalase and increased glucose, hemoglobinA1c and ApoB. Type-2 diabetics who have TT genotype in-262C>T may have elevated risk for diabetes complications; these patients had the lowest mean catalase and HDL, as well as the highest glucose, haemoglobin A1c, cholesterol and ApoB.

Original languageEnglish
Pages (from-to)1249-1257
Number of pages9
JournalFree radical research
Volume46
Issue number10
DOIs
Publication statusPublished - Oct 1 2012

Keywords

  • Catalase gene
  • Catalase polymorphisms
  • Decreased catalase
  • Diabetes mellitus
  • Hydrogen peroxide
  • Reactive oxygen species

ASJC Scopus subject areas

  • Biochemistry

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