Effects of rilmenidine on 24-h rhythmicity of blood pressure and spontaneous baroreflex sensitivity in essential hypertensive subjects

Ervin Finta, Dominique Laude, Sándor Alföldi, C. Farsang, Jean Luc Elghozi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

OBJECTIVE: To study the effects of the centrally acting imidazoline-like compound rilmenidine on the circadian and short-term cardiovascular rhythms derived from continuous blood pressure (BP) recordings in patients with mild essential hypertension. METHODS: This was a single-center, open study. Recordings were obtained from eight subjects, using a Portapres during two 24-h hospitalizations: the first after the inclusion visit and the second 4 weeks after starting rilmenidine treatment (1 or 2 mg/day). For circadian analysis of cardiovascular variables, 10 min were selected every hour to obtain 24 periods per subject for each session. Spontaneous baroreflex sensitivity (BRS) was estimated using the sequence technique and the cross-spectral analysis between systolic BP and interbeat intervals. RESULTS: Rilmenidine significantly reduced the overall systolic and diastolic BP and heart rate (P <0.001). The effects of rilmenidine on BP and heart rhythm were marked during the daytime. Rilmenidine reduced the low-frequency (LF) component of systolic BP variability throughout the 24 h. The highest values of spontaneous BRS were observed at night. Rilmenidine increased the BRS obtained by the slope of the sequence method throughout the 24-h period (P <0.001). The LF gain was significantly increased with rilmenidine during the day and the night. CONCLUSIONS: Rilmenidine may differentially affect the baroreflex-dependent (phasic or reflex) and the baroreflex-independent (tonic) autonomic outflow. The 24-h approach reinforced this concept, since indexes of BRS were increased throughout the 24-h period while BP was reduced during the daytime.

Original languageEnglish
Pages (from-to)1619-1625
Number of pages7
JournalJournal of Hypertension
Volume24
Issue number8
DOIs
Publication statusPublished - Aug 2006

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rilmenidine
Baroreflex
Periodicity
Blood Pressure
Imidazolines

Keywords

  • Antihypertensive agents
  • Circadian rhythms
  • Oxaminozoline
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology

Cite this

Effects of rilmenidine on 24-h rhythmicity of blood pressure and spontaneous baroreflex sensitivity in essential hypertensive subjects. / Finta, Ervin; Laude, Dominique; Alföldi, Sándor; Farsang, C.; Elghozi, Jean Luc.

In: Journal of Hypertension, Vol. 24, No. 8, 08.2006, p. 1619-1625.

Research output: Contribution to journalArticle

Finta, Ervin ; Laude, Dominique ; Alföldi, Sándor ; Farsang, C. ; Elghozi, Jean Luc. / Effects of rilmenidine on 24-h rhythmicity of blood pressure and spontaneous baroreflex sensitivity in essential hypertensive subjects. In: Journal of Hypertension. 2006 ; Vol. 24, No. 8. pp. 1619-1625.
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AU - Elghozi, Jean Luc

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N2 - OBJECTIVE: To study the effects of the centrally acting imidazoline-like compound rilmenidine on the circadian and short-term cardiovascular rhythms derived from continuous blood pressure (BP) recordings in patients with mild essential hypertension. METHODS: This was a single-center, open study. Recordings were obtained from eight subjects, using a Portapres during two 24-h hospitalizations: the first after the inclusion visit and the second 4 weeks after starting rilmenidine treatment (1 or 2 mg/day). For circadian analysis of cardiovascular variables, 10 min were selected every hour to obtain 24 periods per subject for each session. Spontaneous baroreflex sensitivity (BRS) was estimated using the sequence technique and the cross-spectral analysis between systolic BP and interbeat intervals. RESULTS: Rilmenidine significantly reduced the overall systolic and diastolic BP and heart rate (P <0.001). The effects of rilmenidine on BP and heart rhythm were marked during the daytime. Rilmenidine reduced the low-frequency (LF) component of systolic BP variability throughout the 24 h. The highest values of spontaneous BRS were observed at night. Rilmenidine increased the BRS obtained by the slope of the sequence method throughout the 24-h period (P <0.001). The LF gain was significantly increased with rilmenidine during the day and the night. CONCLUSIONS: Rilmenidine may differentially affect the baroreflex-dependent (phasic or reflex) and the baroreflex-independent (tonic) autonomic outflow. The 24-h approach reinforced this concept, since indexes of BRS were increased throughout the 24-h period while BP was reduced during the daytime.

AB - OBJECTIVE: To study the effects of the centrally acting imidazoline-like compound rilmenidine on the circadian and short-term cardiovascular rhythms derived from continuous blood pressure (BP) recordings in patients with mild essential hypertension. METHODS: This was a single-center, open study. Recordings were obtained from eight subjects, using a Portapres during two 24-h hospitalizations: the first after the inclusion visit and the second 4 weeks after starting rilmenidine treatment (1 or 2 mg/day). For circadian analysis of cardiovascular variables, 10 min were selected every hour to obtain 24 periods per subject for each session. Spontaneous baroreflex sensitivity (BRS) was estimated using the sequence technique and the cross-spectral analysis between systolic BP and interbeat intervals. RESULTS: Rilmenidine significantly reduced the overall systolic and diastolic BP and heart rate (P <0.001). The effects of rilmenidine on BP and heart rhythm were marked during the daytime. Rilmenidine reduced the low-frequency (LF) component of systolic BP variability throughout the 24 h. The highest values of spontaneous BRS were observed at night. Rilmenidine increased the BRS obtained by the slope of the sequence method throughout the 24-h period (P <0.001). The LF gain was significantly increased with rilmenidine during the day and the night. CONCLUSIONS: Rilmenidine may differentially affect the baroreflex-dependent (phasic or reflex) and the baroreflex-independent (tonic) autonomic outflow. The 24-h approach reinforced this concept, since indexes of BRS were increased throughout the 24-h period while BP was reduced during the daytime.

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