Effects of reserpine and antidepressants on dopamine and DOPAC (3,4-dihydroxyphenylacetic) concentrations in the striatum, olfactory tubercle and median eminence of rats

Márton I.K. Fekete, Tibor Szentendrei, Jean Paul Herman, Béla Kanyicska

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The dopamine, noradrenaline and 3,4-dihydroxyphenylacetic acid (DOPAC) levels of various rat brain areas (median eminence, olfactory tubercle, rostral and caudal part of the striatum) were measured. The effects of reserpine and antidepressants: amitriptyline, nomifensine and EGYT 475 (1-benzyl-4-/2′-piridycarbonyl/piperazine) were investigated. The dopamine content of the median eminence proved to be the most sensitive to the depletory effect of reserpine. Reserpin (1 mg/kr i.p.) caused a decrease of dopamine in the median eminence, in the olfactory tubercle and in the rostral striatum but not in the caudal striatum. Amitriptyline and EGYT 475 antagonized the reserpine-induce dopamine depletion in the olfactory tubercle. In the median eminence amitriptyline attenuated the effect of the depletor while nomifensine augmented it; EGYT 475 was without effect. The antidepressants antagonized the reserpine-induced increase of DOPAC in the rostral part of the striatum.

Original languageEnglish
Pages (from-to)231-238
Number of pages8
JournalEuropean Journal of Pharmacology
Volume64
Issue number4
DOIs
Publication statusPublished - Jun 27 1980

Keywords

  • Antidepressants
  • DOPAC
  • Dopamine
  • Median eminence
  • Olfactory tubercle
  • Reserpine
  • Striatum

ASJC Scopus subject areas

  • Pharmacology

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