Effects of purified glycerol from biodiesel on miRNAs compared to the expression profile of selected mRNAs in Balb/c mice

Eszter Szele, Katalin Gombos, Krisztina Juhász, Veronika Wohler, András Kovács, István Ember

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: We investigated the effect of corn-derived biodiesel glycerol on microRNAs (miRNAs) and mRNAs, which play a central role in regulating cell survival, apoptosis and carcinogenesis. Materials and Methods: Inbred Balb/c mice were treated with purified glycerol from biodiesel for 24 hours. After administration, we determined the expressions of miR-21, miR-27a, miR-34a, miR-93, miR-143, miR-146a, miR-148a, miR-155, miR-196a, miR-203, miR-205, miR-221 and nuclear factor kappa-light-chain enhancer of activated B-cells-1 (Nfκb1), mitogen-activated protein kinase-8 (Mapk8) and v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-ras) genes in the liver of mice. Results: We found a parallel altered expression of miRNAs and mRNAs in animals consuming biodiesel glycerol that compared to control mice; these alterations reached significant levels only in few cases. Conclusion: Biodiesel glycerol presents no higher risk for carcinogenicity or toxicity.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalIn Vivo
Volume27
Issue number1
Publication statusPublished - Jan 2013

Keywords

  • Biodiesel
  • Gene expression
  • Glycerol
  • K-ras
  • Mapk8
  • MicroRNA
  • Nfκb1
  • Renewable energy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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