Effects of purified glycerol from biodiesel on Cyp1a1 and Cyp2e1 expressions in CBA/CA mice

Eszter Szele, Katalin Gombos, András Kovács, István Ember

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: The glycerol from biodiesel as a valuable by-product can be used as food supplements in feed for animals. We investigated the effect of this by-product on metabolism in mice. Materials and Methods: CBA/CA mice were administered purified glycerol products (called SZME3) for 3, 6 and 24 hours. After dietary exposure, gene expressions of cytochrome P450, family 1, subfamily a polypeptide 1 (Cyp1a1) and cytochrome P450, family 2, subfamily e, polypeptide 1 (Cyp2e1) were analysed in liver. Results: SZME3 induced an up-regulation of both genes in both genders after three hours' administration. After longer administration of SZME3, the expression of genes became similar to that of the controls. Conclusion: Based upon our data SZME3 has no long-term effect on oxidative metabolism, it seems not to cause oxidative stress for liver cells.

Original languageEnglish
Pages (from-to)237-240
Number of pages4
JournalIn Vivo
Volume25
Issue number2
Publication statusPublished - Mar 1 2011

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Keywords

  • Biodiesel
  • Cyp1a1
  • Cyp2e1
  • Gene expression
  • Glycerol
  • Renewable energy

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology

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