Effects of processing on the release profiles of matrix systems containing 5-aminosalicylic acid

Anita Korbely, András Kelemen, Péter Kása, Klára Pintye-Hódi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The aim of this study was to investigate the influence of different processing methods on the profiles of 5-aminosalicylic acid dissolution from controlled-release matrix systems based on Eudragit® RL and Eudragit® RS water-insoluble polymers. The pure polymers and their mixtures were studied as matrix formers using different processing methods, i.e., direct compression, wet granulation of the active ingredient with the addition of polymer(s) to the external phase, wet granulation with water, and wet granulation with aqueous dispersions. In comparison with the directly compressed tablets, tablets made by wet granulation with water demonstrated a 6-19% increase in final drug dissolution, whereas when polymers were applied in the external phase during compression, a 0-13% decrease was observed in the amount of drug released. Wet granulation with aqueous polymer dispersions delayed the release of the drug; this was especially marked (a 54-56% decrease in drug release) in compositions, which contained a high amount of Eudragit RL 30D. The release profiles were mostly described by the Korsmeyer-Peppas model or the Hopfenberg model.

Original languageEnglish
Pages (from-to)1341-1347
Number of pages7
JournalAAPS PharmSciTech
Volume13
Issue number4
DOIs
Publication statusPublished - Dec 1 2012

Keywords

  • controlled release
  • matrix tablet
  • polymethacrylates
  • release kinetics

ASJC Scopus subject areas

  • Pharmaceutical Science

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