Effects of pretreatment with PACAP on the infarct size and functional outcome in rat permanent focal cerebral ischemia

D. Reglodi, A. Tamás, A. Somogyvári-Vigh, Z. Szántó, E. Kertes, L. Lénárd, A. Arimura, I. Lengvári

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

PACAP exerts neuroprotective effects under various neurotoxic conditions in vitro. In vivo, it reduces brain damage after global and transient focal ischemia. The present study investigated whether PACAP has neuroprotective effects when applied before the onset of permanent ischemia. Rats were given bolus injections of PACAP38 intracerebroventricularly, and then underwent permanent middle cerebral artery occlusion. The results show that 2μg of PACAP significantly reduced the infarct size measured 12 and 24h after the onset of ischemia. No further reduction was obtained by a 7-day pretreatment. PACAP also ameliorated certain sensorimotor deficits. Our present study provides further evidence for the neuroprotective effects of PACAP, and implies that it might be a promising preventive therapeutic agent in ameliorating ischemic brain damage.

Original languageEnglish
Pages (from-to)2227-2234
Number of pages8
JournalPeptides
Volume23
Issue number12
DOIs
Publication statusPublished - Dec 1 2002

Keywords

  • Neuropeptides
  • Neuroprotection
  • PACAP
  • Permanent focal cerebral ischemia
  • Rat

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

Fingerprint Dive into the research topics of 'Effects of pretreatment with PACAP on the infarct size and functional outcome in rat permanent focal cerebral ischemia'. Together they form a unique fingerprint.

  • Cite this