Effects of pituitary adenylate cyclase activating polypeptide in the urinary system, with special emphasis on its protective effects in the kidney

Dora Reglodi, Peter Kiss, Gabriella Horvath, Andrea Lubics, Eszter Laszlo, Andrea Tamas, Boglarka Racz, Peter Szakaly

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Pituitary adenylate cyclase activating polypeptide (PACAP) is a widespread neuropeptide with diverse effects in the nervous system and peripheral organs. One of the most well-studied effects of PACAP is its cytoprotective action, against different harmful stimuli in a wide variety of cells and tissues. PACAP occurs in the urinary system, from the kidney to the lower urinary tract. The present review focuses on the nephroprotective effects of PACAP and summarizes data obtained regarding the protective effects of PACAP in different models of kidney pathologies. In vitro data show that PACAP protects tubular cells against oxidative stress, myeloma light chain, cisplatin, cyclosporine-A and hypoxia. In vivo data provide evidence for its protective effects in ischemia/reperfusion, cisplatin, cyclosporine-A, myeloma kidney injury, diabetic nephropathy and gentamicin-induced kidney damage. Results accumulated on the renoprotective effects of PACAP suggest that PACAP is an emerging candidate for treatment of human kidney pathologies.

Original languageEnglish
Pages (from-to)61-70
Number of pages10
JournalNeuropeptides
Volume46
Issue number2
DOIs
Publication statusPublished - Apr 1 2012

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Keywords

  • Cisplatin
  • Cyclosporine-A
  • Ischemia
  • Kidney
  • Myeloma
  • Oxidative stress

ASJC Scopus subject areas

  • Endocrinology
  • Neurology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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