Effects of perineural capsaicin treatment of the abdominal vagus on endotoxin fever and on a non-febrile thermoregulatory event

Erika Pétervári, András Garami, Eszter Pákai, M. Székely

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Following perineural capsaicin pretreatment of the main trunks of the abdominal vagus of rats, the first and the second phases of the polyphasic febrile response to intravenous lipopolysaccharide were unaltered, while the third phase of fever course (peak at 5 h) was attenuated. In rats desensitized by intraperitoneal (i.p.) capsaicin (i.e. abdominal non-systemic desensitization), mainly the first but not the later fever phases were reduced. The postprandial hyperthermia to intragastric injection of BaSO4 suspension was attenuated by either i.p. or perineural capsaicin treatment. It is concluded that, in contrast to the accepted model of postprandial hyperthermia, which is mediated by capsaicin-sensitive fibers of the abdominal vagus, in the early phase of polyphasic fever the vagal afferent nerves appear to play no role. The influence of i.p. capsaicin-desensitization on this initiating fever phase is independent of the vagus, and a capsaicin-induced alteration of endotoxin action in the liver, prior to vagal nerve endings, is more likely. The late febrile phase is probably influenced by efferent vagal fibers, which might be damaged more easily by perineural than i.p. capsaicin treatment.

Original languageEnglish
Pages (from-to)260-266
Number of pages7
JournalJournal of Endotoxin Research
Volume11
Issue number5
DOIs
Publication statusPublished - 2005

Fingerprint

Capsaicin
Endotoxins
Fever
Therapeutics
Rats
Fibers
Nerve Endings
Liver
Lipopolysaccharides
Suspensions
Injections

Keywords

  • Capsaicin
  • Endotoxin
  • Fever
  • Postprandial hyperthermia
  • Vagus

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Toxicology

Cite this

Effects of perineural capsaicin treatment of the abdominal vagus on endotoxin fever and on a non-febrile thermoregulatory event. / Pétervári, Erika; Garami, András; Pákai, Eszter; Székely, M.

In: Journal of Endotoxin Research, Vol. 11, No. 5, 2005, p. 260-266.

Research output: Contribution to journalArticle

@article{299f19f208eb4abe9c9ae35ae6d9b5bd,
title = "Effects of perineural capsaicin treatment of the abdominal vagus on endotoxin fever and on a non-febrile thermoregulatory event",
abstract = "Following perineural capsaicin pretreatment of the main trunks of the abdominal vagus of rats, the first and the second phases of the polyphasic febrile response to intravenous lipopolysaccharide were unaltered, while the third phase of fever course (peak at 5 h) was attenuated. In rats desensitized by intraperitoneal (i.p.) capsaicin (i.e. abdominal non-systemic desensitization), mainly the first but not the later fever phases were reduced. The postprandial hyperthermia to intragastric injection of BaSO4 suspension was attenuated by either i.p. or perineural capsaicin treatment. It is concluded that, in contrast to the accepted model of postprandial hyperthermia, which is mediated by capsaicin-sensitive fibers of the abdominal vagus, in the early phase of polyphasic fever the vagal afferent nerves appear to play no role. The influence of i.p. capsaicin-desensitization on this initiating fever phase is independent of the vagus, and a capsaicin-induced alteration of endotoxin action in the liver, prior to vagal nerve endings, is more likely. The late febrile phase is probably influenced by efferent vagal fibers, which might be damaged more easily by perineural than i.p. capsaicin treatment.",
keywords = "Capsaicin, Endotoxin, Fever, Postprandial hyperthermia, Vagus",
author = "Erika P{\'e}terv{\'a}ri and Andr{\'a}s Garami and Eszter P{\'a}kai and M. Sz{\'e}kely",
year = "2005",
doi = "10.1179/096805105X58689",
language = "English",
volume = "11",
pages = "260--266",
journal = "Innate Immunity",
issn = "1753-4259",
publisher = "SAGE Publications Ltd",
number = "5",

}

TY - JOUR

T1 - Effects of perineural capsaicin treatment of the abdominal vagus on endotoxin fever and on a non-febrile thermoregulatory event

AU - Pétervári, Erika

AU - Garami, András

AU - Pákai, Eszter

AU - Székely, M.

PY - 2005

Y1 - 2005

N2 - Following perineural capsaicin pretreatment of the main trunks of the abdominal vagus of rats, the first and the second phases of the polyphasic febrile response to intravenous lipopolysaccharide were unaltered, while the third phase of fever course (peak at 5 h) was attenuated. In rats desensitized by intraperitoneal (i.p.) capsaicin (i.e. abdominal non-systemic desensitization), mainly the first but not the later fever phases were reduced. The postprandial hyperthermia to intragastric injection of BaSO4 suspension was attenuated by either i.p. or perineural capsaicin treatment. It is concluded that, in contrast to the accepted model of postprandial hyperthermia, which is mediated by capsaicin-sensitive fibers of the abdominal vagus, in the early phase of polyphasic fever the vagal afferent nerves appear to play no role. The influence of i.p. capsaicin-desensitization on this initiating fever phase is independent of the vagus, and a capsaicin-induced alteration of endotoxin action in the liver, prior to vagal nerve endings, is more likely. The late febrile phase is probably influenced by efferent vagal fibers, which might be damaged more easily by perineural than i.p. capsaicin treatment.

AB - Following perineural capsaicin pretreatment of the main trunks of the abdominal vagus of rats, the first and the second phases of the polyphasic febrile response to intravenous lipopolysaccharide were unaltered, while the third phase of fever course (peak at 5 h) was attenuated. In rats desensitized by intraperitoneal (i.p.) capsaicin (i.e. abdominal non-systemic desensitization), mainly the first but not the later fever phases were reduced. The postprandial hyperthermia to intragastric injection of BaSO4 suspension was attenuated by either i.p. or perineural capsaicin treatment. It is concluded that, in contrast to the accepted model of postprandial hyperthermia, which is mediated by capsaicin-sensitive fibers of the abdominal vagus, in the early phase of polyphasic fever the vagal afferent nerves appear to play no role. The influence of i.p. capsaicin-desensitization on this initiating fever phase is independent of the vagus, and a capsaicin-induced alteration of endotoxin action in the liver, prior to vagal nerve endings, is more likely. The late febrile phase is probably influenced by efferent vagal fibers, which might be damaged more easily by perineural than i.p. capsaicin treatment.

KW - Capsaicin

KW - Endotoxin

KW - Fever

KW - Postprandial hyperthermia

KW - Vagus

UR - http://www.scopus.com/inward/record.url?scp=27644458780&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27644458780&partnerID=8YFLogxK

U2 - 10.1179/096805105X58689

DO - 10.1179/096805105X58689

M3 - Article

C2 - 16262998

AN - SCOPUS:27644458780

VL - 11

SP - 260

EP - 266

JO - Innate Immunity

JF - Innate Immunity

SN - 1753-4259

IS - 5

ER -