Effects of perinatal asphyxia on the neurobehavioral and retinal development of newborn rats

P. Kiss, Donat Szogyi, D. Reglodi, Gabor Horvath, Jozsef Farkas, A. Lubics, A. Tamás, Tamas Atlasz, K. Szabadfi, Norbert Babai, R. Gábriel, M. Koppán

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Perinatal asphyxia during delivery produces long-term deficits and represents a major problem in both neonatal and pediatric care. Several morphological, biochemical and behavioral changes have been described in rats exposed to perinatal asphyxia. The aim of the present study was to evaluate how perinatal asphyxia affects the complex early neurobehavioral development and retinal structure of newborn rats. Asphyxia was induced in ready-to-deliver mothers by removing the pups by cesarian section after 15 min of asphyxia. Somatic and neurobehavioral development was tested daily during the first 3 weeks, and motor coordination tests were performed on postnatal weeks 3-5. After completion of the testing procedure, retinas were removed for histological analysis. We found that in spite of the fast catch-up-growth of asphyctic pups, nearly all examined reflexes were delayed by 1-4 days: negative geotaxis, sensory reflexes, righting reflexes, development of fore- and hindlimb grasp and placing, gait and auditory startle reflexes. Time to perform negative geotaxis, surface righting and gait reflexes was significantly longer during the first few weeks in asphyctic pups. Among the motor coordination tests, a markedly weaker performance was observed in the grid walking and footfault test and in the walk initiation test. Retinal structure showed severe degeneration in the layer of the photoreceptor and bipolar cell bodies. In summary, our present study provided a detailed description of reflex and motor development following perinatal asphyxia, showing that asphyxia led to a marked delay in neurobehavioral development and a severe retinal degeneration.

Original languageEnglish
Pages (from-to)42-50
Number of pages9
JournalBrain Research
Volume1255
DOIs
Publication statusPublished - Feb 19 2009

Fingerprint

Asphyxia
Righting Reflex
Reflex
Gait
Startle Reflex
Photoreceptor Cells
Retinal Degeneration
Forelimb
Hand Strength
Hindlimb
Cesarean Section
Walking
Retina
Pediatrics
Growth

Keywords

  • Motor coordination
  • Neurodegeneration
  • Reflex development

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Developmental Biology
  • Molecular Biology

Cite this

Effects of perinatal asphyxia on the neurobehavioral and retinal development of newborn rats. / Kiss, P.; Szogyi, Donat; Reglodi, D.; Horvath, Gabor; Farkas, Jozsef; Lubics, A.; Tamás, A.; Atlasz, Tamas; Szabadfi, K.; Babai, Norbert; Gábriel, R.; Koppán, M.

In: Brain Research, Vol. 1255, 19.02.2009, p. 42-50.

Research output: Contribution to journalArticle

@article{473fdccda82b462581ddbc9c89cff2ad,
title = "Effects of perinatal asphyxia on the neurobehavioral and retinal development of newborn rats",
abstract = "Perinatal asphyxia during delivery produces long-term deficits and represents a major problem in both neonatal and pediatric care. Several morphological, biochemical and behavioral changes have been described in rats exposed to perinatal asphyxia. The aim of the present study was to evaluate how perinatal asphyxia affects the complex early neurobehavioral development and retinal structure of newborn rats. Asphyxia was induced in ready-to-deliver mothers by removing the pups by cesarian section after 15 min of asphyxia. Somatic and neurobehavioral development was tested daily during the first 3 weeks, and motor coordination tests were performed on postnatal weeks 3-5. After completion of the testing procedure, retinas were removed for histological analysis. We found that in spite of the fast catch-up-growth of asphyctic pups, nearly all examined reflexes were delayed by 1-4 days: negative geotaxis, sensory reflexes, righting reflexes, development of fore- and hindlimb grasp and placing, gait and auditory startle reflexes. Time to perform negative geotaxis, surface righting and gait reflexes was significantly longer during the first few weeks in asphyctic pups. Among the motor coordination tests, a markedly weaker performance was observed in the grid walking and footfault test and in the walk initiation test. Retinal structure showed severe degeneration in the layer of the photoreceptor and bipolar cell bodies. In summary, our present study provided a detailed description of reflex and motor development following perinatal asphyxia, showing that asphyxia led to a marked delay in neurobehavioral development and a severe retinal degeneration.",
keywords = "Motor coordination, Neurodegeneration, Reflex development",
author = "P. Kiss and Donat Szogyi and D. Reglodi and Gabor Horvath and Jozsef Farkas and A. Lubics and A. Tam{\'a}s and Tamas Atlasz and K. Szabadfi and Norbert Babai and R. G{\'a}briel and M. Kopp{\'a}n",
year = "2009",
month = "2",
day = "19",
doi = "10.1016/j.brainres.2008.12.018",
language = "English",
volume = "1255",
pages = "42--50",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",

}

TY - JOUR

T1 - Effects of perinatal asphyxia on the neurobehavioral and retinal development of newborn rats

AU - Kiss, P.

AU - Szogyi, Donat

AU - Reglodi, D.

AU - Horvath, Gabor

AU - Farkas, Jozsef

AU - Lubics, A.

AU - Tamás, A.

AU - Atlasz, Tamas

AU - Szabadfi, K.

AU - Babai, Norbert

AU - Gábriel, R.

AU - Koppán, M.

PY - 2009/2/19

Y1 - 2009/2/19

N2 - Perinatal asphyxia during delivery produces long-term deficits and represents a major problem in both neonatal and pediatric care. Several morphological, biochemical and behavioral changes have been described in rats exposed to perinatal asphyxia. The aim of the present study was to evaluate how perinatal asphyxia affects the complex early neurobehavioral development and retinal structure of newborn rats. Asphyxia was induced in ready-to-deliver mothers by removing the pups by cesarian section after 15 min of asphyxia. Somatic and neurobehavioral development was tested daily during the first 3 weeks, and motor coordination tests were performed on postnatal weeks 3-5. After completion of the testing procedure, retinas were removed for histological analysis. We found that in spite of the fast catch-up-growth of asphyctic pups, nearly all examined reflexes were delayed by 1-4 days: negative geotaxis, sensory reflexes, righting reflexes, development of fore- and hindlimb grasp and placing, gait and auditory startle reflexes. Time to perform negative geotaxis, surface righting and gait reflexes was significantly longer during the first few weeks in asphyctic pups. Among the motor coordination tests, a markedly weaker performance was observed in the grid walking and footfault test and in the walk initiation test. Retinal structure showed severe degeneration in the layer of the photoreceptor and bipolar cell bodies. In summary, our present study provided a detailed description of reflex and motor development following perinatal asphyxia, showing that asphyxia led to a marked delay in neurobehavioral development and a severe retinal degeneration.

AB - Perinatal asphyxia during delivery produces long-term deficits and represents a major problem in both neonatal and pediatric care. Several morphological, biochemical and behavioral changes have been described in rats exposed to perinatal asphyxia. The aim of the present study was to evaluate how perinatal asphyxia affects the complex early neurobehavioral development and retinal structure of newborn rats. Asphyxia was induced in ready-to-deliver mothers by removing the pups by cesarian section after 15 min of asphyxia. Somatic and neurobehavioral development was tested daily during the first 3 weeks, and motor coordination tests were performed on postnatal weeks 3-5. After completion of the testing procedure, retinas were removed for histological analysis. We found that in spite of the fast catch-up-growth of asphyctic pups, nearly all examined reflexes were delayed by 1-4 days: negative geotaxis, sensory reflexes, righting reflexes, development of fore- and hindlimb grasp and placing, gait and auditory startle reflexes. Time to perform negative geotaxis, surface righting and gait reflexes was significantly longer during the first few weeks in asphyctic pups. Among the motor coordination tests, a markedly weaker performance was observed in the grid walking and footfault test and in the walk initiation test. Retinal structure showed severe degeneration in the layer of the photoreceptor and bipolar cell bodies. In summary, our present study provided a detailed description of reflex and motor development following perinatal asphyxia, showing that asphyxia led to a marked delay in neurobehavioral development and a severe retinal degeneration.

KW - Motor coordination

KW - Neurodegeneration

KW - Reflex development

UR - http://www.scopus.com/inward/record.url?scp=59049098511&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=59049098511&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2008.12.018

DO - 10.1016/j.brainres.2008.12.018

M3 - Article

C2 - 19118536

AN - SCOPUS:59049098511

VL - 1255

SP - 42

EP - 50

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -