Effects of pectin-induced passive linkage of gastric H+ on the gastric acid secretion and on the development of ethanol- and salicylate-induced gastric mucosal lesions in rats

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Abstract

The aim of this study was to evaluate the effects of intragastrically given pectin-induced physicochemical properties and actions on active gastric acid secretion and on the development of ethanol- and aspirin-induced gastric mucosal lesions. The observations were carded out on CFY-strain rats, fasted for 24 h before the experiments with water ad libitum. The observations were carded out in two experimental series. A) The gastric mucosal lesions were produced by intragastrically given 96% ethanol or aspirin prepared with 0.2 M HCl. Different doses of pectin (100, 50 and 25 mg · kg-1, respectively) were administered intragastrically 30 min before giving necrotizing agents. The number of gastric lesions was noted 1 h after the administration, while the severity of gastric mucosal lesions was scored by semi-quantitative scale. B) The effects of pectin were studied on the volume and H+ secretion of the stomach in 4-h pylorus-ligated rats. It has been found that: 1) the gastric mucosal lesions could be produced in 100% of rats by the application of both necrotizing agents. 2) Pectin in doses of 50-100 mg · kg-1 increased the number of gastric mucosal lesions in both models, while no increase was produced by the application of 25-mg · kg-1 dose. 3) The severity of mucosal lesions increased significantly after the administration of all doses of pectin. 4) The pectin-induced increase of gastric lesions (number) showed a dose-response effect. 5) The pectin produced a significant increase in the volume of gastric secretion and gastric H+ secretion. It has been concluded that: a) pectin-induced physicochemical changes are able to enhance the aggression to gastric mucosa produced by ethanol and aspirin; b) a positive correlation exists between the linkage of H+ to pectin and significant active metabolic response in the rat stomach, c) pectin alone stimulates the active metabolic process of the gastric H+ secretion.

Original languageEnglish
Pages (from-to)495-499
Number of pages5
JournalJournal of Physiology Paris
Volume93
Issue number6
DOIs
Publication statusPublished - Dec 1999

Keywords

  • Dietary fibres
  • Ethanol and aspirin-induced gastric mucosal lesions
  • Gastric H (active and passive) movements from gastric to lumen and vice versa
  • Pectin

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology (medical)

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