Effects of paraventricular lesions on stimulated ACTH release and CRF in stalk-median eminence of the rat.

G. Makara, E. Stark, M. Kárteszi, M. Palkovits, G. Rappay

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Abstract

The effects of destroying the paraventricular nucleus (PVN) of the rat hypothalamus on pituitary-adrenal function were studied. Four days after PVN lesions were placed with a rotating knife, the basal plasma corticosterone level was normal, but the corticosterone response to electrical stimulation of the medial basal hypothalamus, surgical trauma, and ether-venesection stress was significantly inhibited. Four and 8 days after PVN lesioning and adrenalectomy, the basal plasma ACTH level was lower, and the rise of plasma ACTH level elicited by a 3-min ether inhalation was significantly smaller than in the adrenalectomized controls. Corticotropin-releasing factor (CRF) activity in the stalk-median eminence extracts from PVN-lesioned rats was significantly less than in the control extracts. The weight of the adrenals was decreased by both 2 and 4 wk after PVN destruction, and 2 wk after hemiadrenalectomy, the compensatory adrenal hypertrophy was inhibited. The plasma corticosterone response to ether-venesection stress was inhibited only temporarily because it returned to normal by the end of the 4th postoperative week. The results are consistent with the hypothesis that a substantial portion of CRF-containing fibers in the stalk-median eminence region either originate from or run though the PVN or its immediate vicinity.

Original languageEnglish
JournalThe American journal of physiology
Volume240
Issue number4
Publication statusPublished - Apr 1981

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Median Eminence
Paraventricular Hypothalamic Nucleus
Corticotropin-Releasing Hormone
Adrenocorticotropic Hormone
Corticosterone
Ether
Phlebotomy
Middle Hypothalamus
Adrenalectomy
Hypertrophy
Inhalation
Electric Stimulation
Hypothalamus
Weights and Measures
Wounds and Injuries

ASJC Scopus subject areas

  • Medicine(all)

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Effects of paraventricular lesions on stimulated ACTH release and CRF in stalk-median eminence of the rat. / Makara, G.; Stark, E.; Kárteszi, M.; Palkovits, M.; Rappay, G.

In: The American journal of physiology, Vol. 240, No. 4, 04.1981.

Research output: Contribution to journalArticle

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