Effects of noradrenaline and dopamine infusions on arachidonic acid metabolism in man

Tapio Kerttula, Seppo Kaukinen, Asko Riutta, Erkki Seppälä, I. Muchá, Heikki Vapaatalo, Juha Alanko

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

We infused noradrenaline (0.025 μg/kg/min for 60 min, n=7) and dopamine (3.0 μg/kg/min for 60 min, n=6) into healthy male volunteers to study the effects of these catecholamines on in vivo thromboxane A2, prostacyclin and leukotriene E4 production measured as urinary excretions of 11-dehydro-thromboxane (TX) B2, 2,3-dinor-6-keto-prostaglandin (PG) F and leukotriene (LT) E4, respectively. Plasma noradrenaline and dopamine concentrations were 2.9±0.3 and 233±17 nmol/l at the end of the noradrenaline and dopamine infusions, respectively. Noradrenaline decreased thromboxane production and increased leukotriene production almost twofold. It had hardly any effect on prostacyclin production. Dopamine had no significant effects on any of the variables, however it had a tendency to increase prostacyclin and leukotriene production. The results indicate that noradrenaline is a more important modulator of arachidonic acid metabolism than dopamine in vivo.

Original languageEnglish
Pages (from-to)169-178
Number of pages10
JournalThrombosis Research
Volume80
Issue number2
DOIs
Publication statusPublished - Oct 15 1995

Fingerprint

Arachidonic Acid
Dopamine
Norepinephrine
Epoprostenol
Leukotriene E4
Leukotrienes
Thromboxane A2
Thromboxanes
Catecholamines
Healthy Volunteers

Keywords

  • arachidonic acid
  • catecholamines
  • dopamine
  • leukotrienes
  • noradrenaline
  • prostacyclin
  • thromboxane

ASJC Scopus subject areas

  • Hematology
  • Cardiology and Cardiovascular Medicine

Cite this

Kerttula, T., Kaukinen, S., Riutta, A., Seppälä, E., Muchá, I., Vapaatalo, H., & Alanko, J. (1995). Effects of noradrenaline and dopamine infusions on arachidonic acid metabolism in man. Thrombosis Research, 80(2), 169-178. https://doi.org/10.1016/0049-3848(95)00163-L

Effects of noradrenaline and dopamine infusions on arachidonic acid metabolism in man. / Kerttula, Tapio; Kaukinen, Seppo; Riutta, Asko; Seppälä, Erkki; Muchá, I.; Vapaatalo, Heikki; Alanko, Juha.

In: Thrombosis Research, Vol. 80, No. 2, 15.10.1995, p. 169-178.

Research output: Contribution to journalArticle

Kerttula, T, Kaukinen, S, Riutta, A, Seppälä, E, Muchá, I, Vapaatalo, H & Alanko, J 1995, 'Effects of noradrenaline and dopamine infusions on arachidonic acid metabolism in man', Thrombosis Research, vol. 80, no. 2, pp. 169-178. https://doi.org/10.1016/0049-3848(95)00163-L
Kerttula, Tapio ; Kaukinen, Seppo ; Riutta, Asko ; Seppälä, Erkki ; Muchá, I. ; Vapaatalo, Heikki ; Alanko, Juha. / Effects of noradrenaline and dopamine infusions on arachidonic acid metabolism in man. In: Thrombosis Research. 1995 ; Vol. 80, No. 2. pp. 169-178.
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