Effects of non-depolarizing neuromuscular blocking agents on norepinephrine release from human atrial tissue obtained during cardiac surgery

K. Sato, K. Windisch, I. Matko, E. Vízi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We have studied the effect of non-depolarizing neuromuscular blocking agents, at concentrations present in serum during anaesthesia, on release of [3H]-norepinephrine ([3H]NE) from superfused atrial appendage obtained during cardiac surgery from 48 patients. Three of the neuromuscular blocking agents (pancuronium, gallamine and rocuronium), which are known to cause an increase in heart rate during anaesthesia, increased stimulation-evoked release of [3H]NE. In contrast, (+)tubocurarine and pipecuronium, neuromuscular blocking agents that do not cause tachycardia, did not affect release of NE. Org 9487 significantly enhanced release while SZ1677 was ineffective, even at concentrations higher than those expected after administration of a 2 x ED95 dose. Atropine enhanced release. These data suggest that the axon terminals of sympathetic nerves in human heart have muscarinic heteroreceptors whose activation by acetylcholine (ACh) released from the vagal nerve reduces release of NE. This action contributes to lowering of heart rate. Therefore, any neuromuscular blocking agent with antimuscarinic actions and capable of increasing the release of NE may produce tachycardia.

Original languageEnglish
Pages (from-to)904-909
Number of pages6
JournalBritish Journal of Anaesthesia
Volume82
Issue number6
Publication statusPublished - Jun 1999

Fingerprint

Neuromuscular Blocking Agents
Thoracic Surgery
Norepinephrine
Tachycardia
Pipecuronium
Anesthesia
Heart Rate
Gallamine Triethiodide
Pancuronium
Atrial Appendage
Tubocurarine
Muscarinic Antagonists
Presynaptic Terminals
Atropine
Cholinergic Agents
Acetylcholine
Serum

Keywords

  • Heart, heart rate
  • Neuromuscular block
  • Surgery, cardiovascular
  • Sympathetic nervous system, norepinephrine

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Effects of non-depolarizing neuromuscular blocking agents on norepinephrine release from human atrial tissue obtained during cardiac surgery. / Sato, K.; Windisch, K.; Matko, I.; Vízi, E.

In: British Journal of Anaesthesia, Vol. 82, No. 6, 06.1999, p. 904-909.

Research output: Contribution to journalArticle

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