Effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine on the blood-brain barrier permeability in the rat

M. Deli, László Németh, A. Falus, C. Ábrahám

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Histamine plays a role in the regulation of the blood-brain barrier function. In this study, effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine (DPPE), an intracellular histamine binding site antagonist on the cerebrovascular permeability were investigated in control and post-ischemic male Wistar rats. Intravenous administration of DPPE, in a dose of 1 and 5 mg/kg, was not followed by any major clinical change, but 20 mg/kg proved to be toxic. A significantly (P

Original languageEnglish
Pages (from-to)63-72
Number of pages10
JournalEuropean Journal of Pharmacology
Volume387
Issue number1
DOIs
Publication statusPublished - Nov 3 2000

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Histamine Receptors
Poisons
Blood-Brain Barrier
Intravenous Administration
Histamine
Wistar Rats
Permeability
tesmilifene

Keywords

  • Blood-brain barrier
  • Brain edema
  • Cerebral ischemia-reperfusion
  • DPPE (N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine)
  • Histamine
  • Intracellular histamine binding site

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effects of N,N-diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine on the blood-brain barrier permeability in the rat. / Deli, M.; Németh, László; Falus, A.; Ábrahám, C.

In: European Journal of Pharmacology, Vol. 387, No. 1, 03.11.2000, p. 63-72.

Research output: Contribution to journalArticle

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