Effects of neuropeptide Y antagonists on food intake in rats: Differences with cold-adaptation

Erika Pétervári, Márta Balaskó, Boglárka Uzsoki, Miklós Székely

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Hyperphagia followed both central neuropeptide Y (NPY) administration and the presumed increase of endogenous NPY activity after food deprivation. NPY induced greater hyperphagia in cold-adapted than non-adapted rats; fasting of comparable severity caused similar hyperphagia in the two groups. NPY-receptor-antagonist d-Tyr27,36,d-Thr32-NPY(27,36) or functional NPY-antagonist d-myo-inositol-1,2,6-trisphosphate attenuated the hyperphagic effect of both NPY and fasting in non-adapted rats. However, while completely preventing the NPY-hyperphagia, they did not influence the fasting-induced hyperphagia in cold-adapted rats. With cold-adaptation the sensitivity to NPY and to its antagonists increases, but the hypothalamic NPY loses from its fundamental role in the regulation of food intake, and the hyperphagia seen in cold-adaptation may need some other explanation.

Original languageEnglish
Pages (from-to)150-156
Number of pages7
JournalPeptides
Volume27
Issue number1
DOIs
Publication statusPublished - Jan 1 2006

Keywords

  • Cold-adaptation
  • Food intake
  • NPY-receptor-antagonist
  • Neuropeptide Y
  • α-Trinositol

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Endocrinology
  • Cellular and Molecular Neuroscience

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