Effects of neurohypophyseal peptide hormones on alcohol dependence and withdrawal

Gyula Szabó, G. Kovács, G. Telegdy

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

The effect of oxytocin (OXT) and vasopressin (VP) on alcohol withdrawal was investigated. CFLP mice were treated with alternating daily injections of tert-butanol and ethanol for four days, which resulted in physical dependence on ethanol. The severity of withdrawal symptoms was assessed by picrotoxin. The lowest dose (0.02 IU) of each of the peptides precipitated tonic convulsions, while higher doses resulted in different tendencies. OXT-treated mice displayed milder withdrawal symptoms in response to increasing doses of peptide (0.2-2.0 IU). VP showed a U-shaped dose-response effect. The lowest (0.02 IU) and the highest (2.0 IU) doses increased the occurrence of withdrawal convulsions and the frequency of deaths.

Original languageEnglish
Pages (from-to)71-74
Number of pages4
JournalAlcohol and Alcoholism
Volume22
Issue number1
Publication statusPublished - 1987

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Posterior Pituitary Hormones
Substance Withdrawal Syndrome
Peptide Hormones
Oxytocin
Vasopressins
Alcoholism
Seizures
Ethanol
Alcohols
tert-Butyl Alcohol
Picrotoxin
Peptides
Injections

ASJC Scopus subject areas

  • Toxicology
  • Psychiatry and Mental health
  • Medicine (miscellaneous)

Cite this

Effects of neurohypophyseal peptide hormones on alcohol dependence and withdrawal. / Szabó, Gyula; Kovács, G.; Telegdy, G.

In: Alcohol and Alcoholism, Vol. 22, No. 1, 1987, p. 71-74.

Research output: Contribution to journalArticle

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