Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions

L. Berek, D. Szabó, I. B. Petri, Y. Shoyama, Y. H. Lin, J. Molnár

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Solamargine, solasonine, ginsenosides and parishin-related compounds were investigated for their effects on mdr efflux pump of lymphoma cells, and their effects on T cell proliferative assays and cell mediated immune functions, antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell activity of human peripheral mononuclear cells. Solamargine and solasonine were the only drugs which inhibited all of the tested immune functions; however, ginsenoside Rc and Rd enhanced T cell proliferative assays and marginally increased the NK cell activity. The majority of the compounds were not able to reverse the multidrug resistance of mouse lymphoma cells. However, ginsenosides Rc, Rd and parishin C were able to moderately reduce the activity of the efflux pump. Parishin, parishin C and crude extract significantly enhanced the ADCC reaction.

Original languageEnglish
Pages (from-to)151-156
Number of pages6
JournalIn Vivo
Volume15
Issue number2
Publication statusPublished - 2001

Fingerprint

Ginsenosides
T-cells
Glucosides
Multiple Drug Resistance
Cytotoxicity
Assays
Lymphoma
Leukocytes
Pumps
Derivatives
Antibodies
Complex Mixtures
Natural Killer Cells
Cells
T-Lymphocytes
Human Activities
Pharmaceutical Preparations
parishin C
solasodine
beta-solamarine

Keywords

  • ADCC
  • Blast transformation
  • Glycosides
  • Immunomodulating effect
  • mdr-reversal
  • NK reaction

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions. / Berek, L.; Szabó, D.; Petri, I. B.; Shoyama, Y.; Lin, Y. H.; Molnár, J.

In: In Vivo, Vol. 15, No. 2, 2001, p. 151-156.

Research output: Contribution to journalArticle

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