Effects of mycotoxins on human immune functions in vitro

L. Berek, I. B. Petri, Á Mesterházy, J. Téren, J. Molnár

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Immunosuppressive and carcinogenic Fusarium mycotoxins may appear in domestic food products. Therefore, the immunological effects of Fusarium mycotoxins were tested on human peripheral blood mononuclear cells from different blood donors. In the present study we investigated deoxynivalenol (DON), 3-acetyldeoxynivalenol, fusarenon-X, T-2 toxin, zearalenone, α-zearalenol, β-zearalenol and nivalenol for their effects on T and B cells in a proliferation assay, antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell activity on human peripheral blood mononuclear cells. The concentrations applied in our experiments were similar to those which can be found in normal human peripheral blood system (0.2-1800 ng/ml). Among the eight mycotoxins tested, T-2 toxin, fusarenon X, nivalenol and deoxynivalenol exerted the highest immunosuppressing effect on human peripheral blood mononuclear cells in vitro. Mycotoxin-induced immunosupression was manifested as depressed T or B lymphocyte activity. Furthermore, by virtue of inhibition of NK cell activity, the protection against tumor development may also be attenuated.

Original languageEnglish
Pages (from-to)25-30
Number of pages6
JournalToxicology in Vitro
Volume15
Issue number1
DOIs
Publication statusPublished - 2001

Fingerprint

Mycotoxins
Blood
T-2 Toxin
Blood Cells
Fusarium
Natural Killer Cells
B-Lymphocytes
Zearalenone
T-Lymphocytes
Cytoprotection
Immunosuppressive Agents
Blood Donors
Human Activities
Lymphocytes
Cytotoxicity
Tumors
Assays
Food
Cells
In Vitro Techniques

Keywords

  • ADCC reaction
  • Blast transformation
  • Fusarium mycotoxins
  • Immunomodulating effect
  • NK cell activity

ASJC Scopus subject areas

  • Toxicology

Cite this

Effects of mycotoxins on human immune functions in vitro. / Berek, L.; Petri, I. B.; Mesterházy, Á; Téren, J.; Molnár, J.

In: Toxicology in Vitro, Vol. 15, No. 1, 2001, p. 25-30.

Research output: Contribution to journalArticle

Berek, L. ; Petri, I. B. ; Mesterházy, Á ; Téren, J. ; Molnár, J. / Effects of mycotoxins on human immune functions in vitro. In: Toxicology in Vitro. 2001 ; Vol. 15, No. 1. pp. 25-30.
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