Effects of methysergide, bromocriptine and naloxone on prolactin, growth hormone and TSH release induced by d-Met2,Pro5-enkephalinamide in man

J. Földes, A. Váradi, A. Gara, C. Bános, P. Vargha, K. Török, J. I. Székely

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

d-Met2,Pro5-enkephalinamide (EA) 10 mg, given SC, induced a dramatic rise in serum prolactin (PRL) and growth hormone (GH) levels in healthy male volunteers. The TSH content was also moderately elevated. Naloxone 0.8 mg administered IV abolished these effects. Bromocriptine 2.5 mg given per os also antagonized EA-induced PRL and TSH release but potentiated the GH surge. Methysergide 2.0 mg administered orally partially reversed EA-elicited PRL release, further augmented GH liberation and did not modify TSH output. The data indicate that inhibition of the dopaminergic tone and/or activation of certain serotonergic mechanisms play an important role in the EA-induced release of PRL and TSH. However, primarily other neurotransmitters might mediate the GH liberation elicited by this opioid peptide.

Original languageEnglish
Pages (from-to)331-335
Number of pages5
JournalPsychopharmacology
Volume88
Issue number3
DOIs
Publication statusPublished - Mar 1 1986

Keywords

  • Bromocriptine
  • Dopaminergic agonists
  • Growth hormone
  • Methysergide
  • Opioid peptides
  • Prolactin
  • Serotonergic antagonists
  • TSH
  • d-Met,Pro-enkephalina-mide

ASJC Scopus subject areas

  • Pharmacology

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