Effects of maternal epilepsy and antiepileptic therapy in women during pregnancy

Melinda Vanya, Nóra Árva-Nagy, Károly Szili, Délia Szok, G. Bártfai

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: The aim of this study was to analyse the effects of epilepsy and antiepileptic drug (AED) treatment on pregnancy and the perinatal outcome, retrospedively. Methods: We examined the obstetric and fetal outcomes among women with epilepsy (WWE), who were followed-up at the Department of Neurology, and who delivered at the Department of Obstetrics and Gynaecology (n=91) belween 31th December 2000 and 31th March 2014. Statistical comparisons of different obstetric and fetal parameters on a sample of 91 WWE and 182 non-WWE were assessed by the chi-square-test, the independent sample t-test. Results: The rate of major congenital malformations (MCMS) among the newborns of all AEDs exposed mothers was 7.69%. There were three peaks of seizures: during the third trimester, during delivery and in the puerperium. The prevalence of miscarriages, post-term birth and the rate of caesarean sedion were significantly higher among the WWE than among the non-WWE (p=0.001; p

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalIdeggyógyászati szemle
Volume68
Issue number3-4
Publication statusPublished - Mar 30 2015

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Anticonvulsants
Epilepsy
Mothers
Pregnancy
Obstetrics
Therapeutics
Term Birth
Hospital Obstetrics and Gynecology Department
Birth Rate
Third Pregnancy Trimester
Spontaneous Abortion
Chi-Square Distribution
Pregnancy Outcome
Neurology
Gynecology
Postpartum Period
Seizures
Newborn Infant

Keywords

  • Antiepileptic therapy
  • Epileptic seizures during pregnancy
  • Major congenital malformations
  • Pregnancy outcomes

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology
  • Medicine(all)

Cite this

Effects of maternal epilepsy and antiepileptic therapy in women during pregnancy. / Vanya, Melinda; Árva-Nagy, Nóra; Szili, Károly; Szok, Délia; Bártfai, G.

In: Ideggyógyászati szemle, Vol. 68, No. 3-4, 30.03.2015, p. 105-112.

Research output: Contribution to journalArticle

Vanya, M, Árva-Nagy, N, Szili, K, Szok, D & Bártfai, G 2015, 'Effects of maternal epilepsy and antiepileptic therapy in women during pregnancy', Ideggyógyászati szemle, vol. 68, no. 3-4, pp. 105-112.
Vanya, Melinda ; Árva-Nagy, Nóra ; Szili, Károly ; Szok, Délia ; Bártfai, G. / Effects of maternal epilepsy and antiepileptic therapy in women during pregnancy. In: Ideggyógyászati szemle. 2015 ; Vol. 68, No. 3-4. pp. 105-112.
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