Effects of magnesium supplementation on the glutathione redox system in atopic asthmatic children

O. Bede, D. Nagy, A. Surányi, I. Horváth, M. Szlávik, K. Gyurkovits

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Objective: Our aim was to investigate the effects of 12-week oral magnesium (Mg) supplementation on the RBC redox system in stable, persistent, moderately asthmatic children (N = 40, 24 boys, 16 girls) aged 4-16 years in a randomized, double-blind, placebo-controlled study. Design: Oxidized (GSSG) and reduced (GSH) glutathione, oxyhaemoglobin, methaemoglobin (metHb), hemichrome and bilirubin levels before and after treatment were determined, and GSH stability tests were performed. Result: The GSH concentration was significantly higher in the Mg-treated than in the placebo-treated patients after the treatment period. There was a positive correlation between the decreased plasma metHb and hemichrome levels and the decreased plasma haemoglobin concentrations in the Mg-treated patients at the end of the study. Conclusion: Mg in the given doses exerts antioxidant activity and influences the glutathione redox system.

Original languageEnglish
Pages (from-to)279-286
Number of pages8
JournalInflammation Research
Volume57
Issue number6
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Magnesium
Oxidation-Reduction
Glutathione
Methemoglobin
Placebos
Plasmas
Oxyhemoglobins
Glutathione Disulfide
Bilirubin
Hemoglobins
Antioxidants
Therapeutics
hemichrome

Keywords

  • Bronchial asthma
  • Glutathione redox system
  • Magnesium supplementation
  • Oxidative stress

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology (medical)
  • Immunology
  • Cell Biology

Cite this

Effects of magnesium supplementation on the glutathione redox system in atopic asthmatic children. / Bede, O.; Nagy, D.; Surányi, A.; Horváth, I.; Szlávik, M.; Gyurkovits, K.

In: Inflammation Research, Vol. 57, No. 6, 06.2008, p. 279-286.

Research output: Contribution to journalArticle

@article{290d3e4e8f144ca4b52f08b7560bcec7,
title = "Effects of magnesium supplementation on the glutathione redox system in atopic asthmatic children",
abstract = "Objective: Our aim was to investigate the effects of 12-week oral magnesium (Mg) supplementation on the RBC redox system in stable, persistent, moderately asthmatic children (N = 40, 24 boys, 16 girls) aged 4-16 years in a randomized, double-blind, placebo-controlled study. Design: Oxidized (GSSG) and reduced (GSH) glutathione, oxyhaemoglobin, methaemoglobin (metHb), hemichrome and bilirubin levels before and after treatment were determined, and GSH stability tests were performed. Result: The GSH concentration was significantly higher in the Mg-treated than in the placebo-treated patients after the treatment period. There was a positive correlation between the decreased plasma metHb and hemichrome levels and the decreased plasma haemoglobin concentrations in the Mg-treated patients at the end of the study. Conclusion: Mg in the given doses exerts antioxidant activity and influences the glutathione redox system.",
keywords = "Bronchial asthma, Glutathione redox system, Magnesium supplementation, Oxidative stress",
author = "O. Bede and D. Nagy and A. Sur{\'a}nyi and I. Horv{\'a}th and M. Szl{\'a}vik and K. Gyurkovits",
year = "2008",
month = "6",
doi = "10.1007/s00011-007-7077-3",
language = "English",
volume = "57",
pages = "279--286",
journal = "Inflammation Research",
issn = "1023-3830",
publisher = "Birkhauser Verlag Basel",
number = "6",

}

TY - JOUR

T1 - Effects of magnesium supplementation on the glutathione redox system in atopic asthmatic children

AU - Bede, O.

AU - Nagy, D.

AU - Surányi, A.

AU - Horváth, I.

AU - Szlávik, M.

AU - Gyurkovits, K.

PY - 2008/6

Y1 - 2008/6

N2 - Objective: Our aim was to investigate the effects of 12-week oral magnesium (Mg) supplementation on the RBC redox system in stable, persistent, moderately asthmatic children (N = 40, 24 boys, 16 girls) aged 4-16 years in a randomized, double-blind, placebo-controlled study. Design: Oxidized (GSSG) and reduced (GSH) glutathione, oxyhaemoglobin, methaemoglobin (metHb), hemichrome and bilirubin levels before and after treatment were determined, and GSH stability tests were performed. Result: The GSH concentration was significantly higher in the Mg-treated than in the placebo-treated patients after the treatment period. There was a positive correlation between the decreased plasma metHb and hemichrome levels and the decreased plasma haemoglobin concentrations in the Mg-treated patients at the end of the study. Conclusion: Mg in the given doses exerts antioxidant activity and influences the glutathione redox system.

AB - Objective: Our aim was to investigate the effects of 12-week oral magnesium (Mg) supplementation on the RBC redox system in stable, persistent, moderately asthmatic children (N = 40, 24 boys, 16 girls) aged 4-16 years in a randomized, double-blind, placebo-controlled study. Design: Oxidized (GSSG) and reduced (GSH) glutathione, oxyhaemoglobin, methaemoglobin (metHb), hemichrome and bilirubin levels before and after treatment were determined, and GSH stability tests were performed. Result: The GSH concentration was significantly higher in the Mg-treated than in the placebo-treated patients after the treatment period. There was a positive correlation between the decreased plasma metHb and hemichrome levels and the decreased plasma haemoglobin concentrations in the Mg-treated patients at the end of the study. Conclusion: Mg in the given doses exerts antioxidant activity and influences the glutathione redox system.

KW - Bronchial asthma

KW - Glutathione redox system

KW - Magnesium supplementation

KW - Oxidative stress

UR - http://www.scopus.com/inward/record.url?scp=46449117292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=46449117292&partnerID=8YFLogxK

U2 - 10.1007/s00011-007-7077-3

DO - 10.1007/s00011-007-7077-3

M3 - Article

C2 - 18516713

AN - SCOPUS:46449117292

VL - 57

SP - 279

EP - 286

JO - Inflammation Research

JF - Inflammation Research

SN - 1023-3830

IS - 6

ER -