SLE lymphocytotoxins can be demonstrated on lymphocytes by immunofluorescence. Complement addition lyses the cells covered with lymphocytotoxin (LCT). The proportion of B and T cells as determined by surface immunoglobulins and spontaneous rosette formation of lymphocytes from healthy donors remains unchanged after LCT and complement treatment. The proportion of B and T cells of SLE lymphocytes was altered after cell lysis. The B cells seemed to be relatively resistant, and the T cells more susceptible, to autologous LCT. Thus the relative decrease in the number of T cells in active SLE may be the consequence of surface bound LCT with its effects of the circulating T cells.
|Number of pages||6|
|Journal||Acta medica Academiae Scientiarum Hungaricae|
|Publication status||Published - Dec 1 1975|
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