Effects of lymphocytotoxins of systemic lupus erythematosus (SLE) sera on T and B lymphocytes

P. Gergely, Gy Szegedi, G. Szabó, B. Fekete, G. Petrányi

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Abstract

SLE lymphocytotoxins can be demonstrated on lymphocytes by immunofluorescence. Complement addition lyses the cells covered with lymphocytotoxin (LCT). The proportion of B and T cells as determined by surface immunoglobulins and spontaneous rosette formation of lymphocytes from healthy donors remains unchanged after LCT and complement treatment. The proportion of B and T cells of SLE lymphocytes was altered after cell lysis. The B cells seemed to be relatively resistant, and the T cells more susceptible, to autologous LCT. Thus the relative decrease in the number of T cells in active SLE may be the consequence of surface bound LCT with its effects of the circulating T cells.

Original languageEnglish
Pages (from-to)43-48
Number of pages6
JournalActa medica Academiae Scientiarum Hungaricae
Volume32
Issue number1-2
Publication statusPublished - Dec 1 1975

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ASJC Scopus subject areas

  • Medicine(all)

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